General Information of the Compound
Compound ID
CP0237075
Compound Name
4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-[1,3,5]triazin-2-ylamino}-ethyl)-phenol
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Structure
Formula
C27H36ClN7O2
Molecular Weight
526.085
Canonical SMILES
CN(CCCc1ccc(Cl)cc1)c1nc(NCCc2ccc(O)cc2)nc(n1)N1CCN(CCO)CC1
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InChI
InChI=1S/C27H36ClN7O2/c1-33(14-2-3-21-4-8-23(28)9-5-21)26-30-25(29-13-12-22-6-10-24(37)11-7-22)31-27(32-26)35-17-15-34(16-18-35)19-20-36/h4-11,36-37H,2-3,12-20H2,1H3,(H,29,30,31,32)
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InChIKey
FFIKIRZWTPILOL-UHFFFAOYSA-N
Physicochemical Property
logP
3.0685
Rotatable Bonds
12
Heavy Atom Count
37
Polar Areas
100.88
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
9
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11071460
SID: 16139799
ChEMBL ID
CHEMBL347560
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00886, Estrogen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  2
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
2
IC50 = 30 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 395 nM
Protein ID: PT00889, Estrogen receptor beta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 15 nM