General Information of the Compound
Compound ID
CP0233746
Compound Name
4-[[(2S)-3,3-dimethylbutan-2-yl]amino]-7-(1-methylpyrazol-4-yl)-9H-carbazole-1-carboxamide
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Structure
Formula
C23H27N5O
Molecular Weight
389.503
Canonical SMILES
C[C@H](Nc1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)-c1cnn(C)c1)C(C)(C)C
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InChI
InChI=1S/C23H27N5O/c1-13(23(2,3)4)26-18-9-8-17(22(24)29)21-20(18)16-7-6-14(10-19(16)27-21)15-11-25-28(5)12-15/h6-13,26-27H,1-5H3,(H2,24,29)/t13-/m0/s1
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InChIKey
LUNNEKXNBPTSAG-ZDUSSCGKSA-N
Physicochemical Property
logP
4.667
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
88.73
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56683053
ChEMBL ID
CHEMBL1835039
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000082 HEL Homo sapiens (Human)  1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5 nM