General Information of the Compound
Compound ID
CP0229013
Compound Name
(1E,4E)-1,5-bis[4-hydroxy-3-methoxy-5-(3-methylbut-2-enyl)phenyl]penta-1,4-dien-3-one
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Structure
Formula
C29H34O5
Molecular Weight
462.586
Canonical SMILES
COc1cc(\C=C\C(=O)\C=C\c2cc(CC=C(C)C)c(O)c(OC)c2)cc(CC=C(C)C)c1O
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InChI
InChI=1S/C29H34O5/c1-19(2)7-11-23-15-21(17-26(33-5)28(23)31)9-13-25(30)14-10-22-16-24(12-8-20(3)4)29(32)27(18-22)34-6/h7-10,13-18,31-32H,11-12H2,1-6H3/b13-9+,14-10+
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InChIKey
AGFUAPYONOPZQE-UTLPMFLDSA-N
Physicochemical Property
logP
6.4281
Rotatable Bonds
10
Heavy Atom Count
34
Polar Areas
75.99
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73356550
ChEMBL ID
CHEMBL2392188
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02025, Prostaglandin E synthase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 1500 nM
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   LI
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Protein ID: PT01503, Signal transducer and activator of transcription 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000150 HaCaT Homo sapiens (Human)  1
1
IC50 = 22400 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1 Homo sapiens (Human)  1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS