General Information of the Compound
Compound ID
CP0205773
Compound Name
1-(dicyclopropylmethylamino)-7-pyridazin-3-yl-5H-pyrido[4,3-b]indole-4-carboxamide
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Structure
Formula
C23H22N6O
Molecular Weight
398.47
Canonical SMILES
NC(=O)c1cnc(NC(C2CC2)C2CC2)c2c3ccc(cc3[nH]c12)-c1cccnn1
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InChI
InChI=1S/C23H22N6O/c24-22(30)16-11-25-23(28-20(12-3-4-12)13-5-6-13)19-15-8-7-14(10-18(15)27-21(16)19)17-2-1-9-26-29-17/h1-2,7-13,20,27H,3-6H2,(H2,24,30)(H,25,28)
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InChIKey
MJSGAQVMOHSLBX-UHFFFAOYSA-N
Physicochemical Property
logP
3.8725
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
109.58
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 42636016
SID: 81075064
ChEMBL ID
CHEMBL1835147
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000082 HEL Homo sapiens (Human)  1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2 nM