General Information of the Compound
Compound ID
CP0204754
Compound Name
1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]imidazol-2-amine
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Synonyms
1-((4-Flurophenyl)methyl)-N-4-piperidinyl-1H-benzimidazol-2-amine
1-(-Fluorobenzyl)-N-(piperidin-4-yl)-1H-benzimidazol-2-amine
1-(4-fluorobenzyl)-n-(piperidin-4-yl)-1h-benzimidazol-2-amine
1H-Benzimidazol-2-amine, 1-((4-fluorophenyl)methyl)-N-4-piperidinyl-
75970-64-8
75970-99-9
AC1L3WZJ
AC1Q4NSA
CHEMBL61301
DTXSID30226877
Norastemizole
SCHEMBL18200
Soltara
T 1348
Tecastemizole
Tecastemizole (USAN/INN)
Tecastemizole [USAN:INN]
Tecastemizole[USAN]
UNII-W5DCO14M05
W5DCO14M05
ZINC2303
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Structure
Formula
C19H21FN4
Molecular Weight
324.403
Canonical SMILES
Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc23)cc1
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InChI
InChI=1S/C19H21FN4/c20-15-7-5-14(6-8-15)13-24-18-4-2-1-3-17(18)23-19(24)22-16-9-11-21-12-10-16/h1-8,16,21H,9-13H2,(H,22,23)
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InChIKey
SFOVDSLXFUGAIV-UHFFFAOYSA-N
Physicochemical Property
logP
3.3876
Rotatable Bonds
4
Heavy Atom Count
24
Polar Areas
41.88
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 123618
SID: 14777201
ChEMBL ID
CHEMBL61301
DrugBank ID
DB06457
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 27.54 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 28.18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 28.18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Norastemizole )
Drug Name Norastemizole
Target(s)
Histamine H1 receptor (H1R)
 Target Info 
Modulator