General Information of the Compound
Compound ID
CP0195644
Compound Name
2-[4-[(4-amino-2-propan-2-ylpyrimidin-5-yl)methyl]-3-methylthiophen-2-yl]ethanol
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Structure
Formula
C15H21N3OS
Molecular Weight
291.42
Canonical SMILES
CC(C)c1ncc(Cc2csc(CCO)c2C)c(N)n1
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InChI
InChI=1S/C15H21N3OS/c1-9(2)15-17-7-11(14(16)18-15)6-12-8-20-13(4-5-19)10(12)3/h7-9,19H,4-6H2,1-3H3,(H2,16,17,18)
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InChIKey
OOQRXXFASFGVQD-UHFFFAOYSA-N
Physicochemical Property
logP
2.67772
Rotatable Bonds
5
Heavy Atom Count
20
Polar Areas
72.03
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44455385
ChEMBL ID
CHEMBL255550
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01640, Transketolase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
EC50 = 2600 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 64 nM