General Information of the Compound
Compound ID
CP0166832
Compound Name
3-{4-[3-(2-benzoyl-4-ethyl-phenoxy)-pentyloxy]-2-methyl-phenyl}-propionic acid
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Structure
Formula
C30H34O5
Molecular Weight
474.597
Canonical SMILES
CCC(CCOc1ccc(CCC(O)=O)c(C)c1)Oc1ccc(CC)cc1C(=O)c1ccccc1
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InChI
InChI=1S/C30H34O5/c1-4-22-11-15-28(27(20-22)30(33)24-9-7-6-8-10-24)35-25(5-2)17-18-34-26-14-12-23(21(3)19-26)13-16-29(31)32/h6-12,14-15,19-20,25H,4-5,13,16-18H2,1-3H3,(H,31,32)
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InChIKey
KEUWMDZMXVQKJB-UHFFFAOYSA-N
Physicochemical Property
logP
6.43212
Rotatable Bonds
13
Heavy Atom Count
35
Polar Areas
72.83
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16085984
SID: 24731982
ChEMBL ID
CHEMBL215127
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
EC50 = 2929 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 8919 nM
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6 nM
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 18 nM