General Information of the Compound
Compound ID
CP0166592
Compound Name
N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide
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Structure
Formula
C25H27Cl2N3O
Molecular Weight
456.417
Canonical SMILES
Clc1cccc(N2CCN(CCCCNC(=O)c3ccc4ccccc4c3)CC2)c1Cl
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InChI
InChI=1S/C25H27Cl2N3O/c26-22-8-5-9-23(24(22)27)30-16-14-29(15-17-30)13-4-3-12-28-25(31)21-11-10-19-6-1-2-7-20(19)18-21/h1-2,5-11,18H,3-4,12-17H2,(H,28,31)
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InChIKey
DTWIWINSMXUYHB-UHFFFAOYSA-N
Physicochemical Property
logP
5.4788
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10939408
SID: 15991887
ChEMBL ID
CHEMBL154508
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1149 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 5200 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Ki = 1.08 nM
   TI
   LI
   LO
   TS
2
Ki = 7.9 nM
   TI
   LI
   LO
   TS