General Information of the Compound
Compound ID
CP0144743
Compound Name
4'-chloro-biphenyl-4-sulfonic acid (8-isopropylamino-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide
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Structure
Formula
C26H30ClN3O2S
Molecular Weight
484.065
Canonical SMILES
CC(C)Nc1cc2CCN(C)CCc2cc1NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1
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InChI
InChI=1S/C26H30ClN3O2S/c1-18(2)28-25-16-21-12-14-30(3)15-13-22(21)17-26(25)29-33(31,32)24-10-6-20(7-11-24)19-4-8-23(27)9-5-19/h4-11,16-18,28-29H,12-15H2,1-3H3
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InChIKey
LQYNONCEAYAGNN-UHFFFAOYSA-N
Physicochemical Property
logP
5.6585
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
61.44
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44425719
ChEMBL ID
CHEMBL231350
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 50.12 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.162 nM
   TI
   LI
   LO
   TS