General Information of the Compound
Compound ID
CP0110334
Compound Name
6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihydro-quinoline
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Structure
Formula
C16H16BrNS
Molecular Weight
334.282
Canonical SMILES
CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1
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InChI
InChI=1S/C16H16BrNS/c1-10-8-16(2,3)18-14-5-4-11(6-13(10)14)15-7-12(17)9-19-15/h4-9,18H,1-3H3
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InChIKey
QRGCGNOXVSPDPZ-UHFFFAOYSA-N
Physicochemical Property
logP
5.785
Rotatable Bonds
1
Heavy Atom Count
19
Polar Areas
12.03
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
19

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44354630
ChEMBL ID
CHEMBL538158
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  2
1
EC50 = 2700 nM
   TI
   LI
   LO
   TS
2
IC50 = 105 nM
   TI
   LI
   LO
   TS
CL000078 T-47D Homo sapiens (Human)  2
1
EC50 = 3500 nM
   TI
   LI
   LO
   TS
2
IC50 = 190 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 32 nM
2 Ki = 32.36 nM