General Information of the Compound
Compound ID
CP0105803
Compound Name
1'-[3-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]spiro[2,3-dihydrochromene-4,3'-pyrrolidine]
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Structure
Formula
C22H27N5O2S
Molecular Weight
425.558
Canonical SMILES
Cc1ncoc1-c1nnc(SCCCN2CCC3(C2)CCOc2ccccc32)n1C
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InChI
InChI=1S/C22H27N5O2S/c1-16-19(29-15-23-16)20-24-25-21(26(20)2)30-13-5-10-27-11-8-22(14-27)9-12-28-18-7-4-3-6-17(18)22/h3-4,6-7,15H,5,8-14H2,1-2H3
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InChIKey
KYBVEQYZQWILGN-UHFFFAOYSA-N
Physicochemical Property
logP
3.68692
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
69.21
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24758838
SID: 103053750
ChEMBL ID
CHEMBL1258606
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 3162.28 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 100 nM
   TI
   LI
   LO
   TS