General Information of the Compound
Compound ID
CP0100831
Compound Name
5-[5-[3-(5-fluorospiro[1,2-dihydroindene-3,3'-pyrrolidine]-1'-yl)propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2,4-dimethyl-1,3-thiazole
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Structure
Formula
C23H28FN5S2
Molecular Weight
457.644
Canonical SMILES
Cc1nc(C)c(s1)-c1nnc(SCCCN2CCC3(CCc4ccc(F)cc34)C2)n1C
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InChI
InChI=1S/C23H28FN5S2/c1-15-20(31-16(2)25-15)21-26-27-22(28(21)3)30-12-4-10-29-11-9-23(14-29)8-7-17-5-6-18(24)13-19(17)23/h5-6,13H,4,7-12,14H2,1-3H3
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InChIKey
AEUDDHALUDWNEZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.76664
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
46.84
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24758945
SID: 103053973
ChEMBL ID
CHEMBL1257214
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 398.11 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 50.12 nM
   TI
   LI
   LO
   TS