General Information of the Compound
Compound ID
CP0097602
Compound Name
2-fluoro-5-[2-oxo-3-[2-[4-(trifluoromethyl)piperidin-1-yl]ethyl]imidazolidin-1-yl]benzonitrile
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Structure
Formula
C18H20F4N4O
Molecular Weight
384.377
Canonical SMILES
Fc1ccc(cc1C#N)N1CCN(CCN2CCC(CC2)C(F)(F)F)C1=O
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InChI
InChI=1S/C18H20F4N4O/c19-16-2-1-15(11-13(16)12-23)26-10-9-25(17(26)27)8-7-24-5-3-14(4-6-24)18(20,21)22/h1-2,11,14H,3-10H2
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InChIKey
HGYQVRAMBVYKQO-UHFFFAOYSA-N
Physicochemical Property
logP
3.21368
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
50.58
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45271516
ChEMBL ID
CHEMBL554073
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 7.943 nM
   TI
   LI
   LO
   TS