General Information of the Compound
Compound ID
CP0089216
Compound Name
1-(3-methoxyphenyl)-3-[2-[4-(trifluoromethyl)piperidin-1-yl]ethyl]imidazolidin-2-one
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Structure
Formula
C18H24F3N3O2
Molecular Weight
371.403
Canonical SMILES
COc1cccc(c1)N1CCN(CCN2CCC(CC2)C(F)(F)F)C1=O
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InChI
InChI=1S/C18H24F3N3O2/c1-26-16-4-2-3-15(13-16)24-12-11-23(17(24)25)10-9-22-7-5-14(6-8-22)18(19,20)21/h2-4,13-14H,5-12H2,1H3
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InChIKey
JTHVEMXEJRSLPM-UHFFFAOYSA-N
Physicochemical Property
logP
3.2115
Rotatable Bonds
5
Heavy Atom Count
26
Polar Areas
36.02
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45268142
ChEMBL ID
CHEMBL559920
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 158.49 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS