General Information of the Compound
Compound ID
CP0086615
Compound Name
1-[(1-cyclopropyl-2-methylpropyl)amino]-7-(1-methylpyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide
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Structure
Formula
C23H26N6O
Molecular Weight
402.502
Canonical SMILES
CC(C)C(Nc1ncc(C(N)=O)c2[nH]c3cc(ccc3c12)-c1cnn(C)c1)C1CC1
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InChI
InChI=1S/C23H26N6O/c1-12(2)20(13-4-5-13)28-23-19-16-7-6-14(15-9-26-29(3)11-15)8-18(16)27-21(19)17(10-25-23)22(24)30/h6-13,20,27H,4-5H2,1-3H3,(H2,24,30)(H,25,28)
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InChIKey
IJGITWYHJMNRMO-UHFFFAOYSA-N
Physicochemical Property
logP
4.062
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
101.62
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 42635982
SID: 81075027
ChEMBL ID
CHEMBL1835140
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000082 HEL Homo sapiens (Human)  1
1
IC50 = 95 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3 nM