General Information of the Compound
Compound ID
CP0082020
Compound Name
33379
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Synonyms
6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with acetone
6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxyprogesterone cyclic 16,17-acetal with acetone
6alpha-Fluoro-16alpha-hydroxyhydrocortisone 16,17-acetonide
Acetonide of 6alpha-fluoro-16alpha-hydroxyhydrocortisone
Alondra-F
CORDRAN (TN)
CORDRAN SP
Cordran
Cordran tape (TN)
Drenison
Drocort
Floudroxycortide
Fludrossicortide
Fludrossicortide [DCIT]
Fludroxicortida
Fludroxicortida [INN-Spanish]
Fludroxicortidum
Fludroxycortide
Fludroxycortide (JAN/INN)
Fludroxycortidum
Fludroxycortidum [INN-Latin]
Fluorandrenolone
Fluorandrenolone acetonide
Fluradrenolide
Flurandrenolide
Flurandrenolide (USP)
Flurandrenolide [USAN]
Flurandrenolone
Flurandrenolone acetonide
Haelan
Haldrone-F
L 33379
Pregn-4-ene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
Pregn-4-ene-3,20-dione, 6alpha-fluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
Sermaka
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Structure
Formula
C24H33FO6
Molecular Weight
436.52
Canonical SMILES
CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO
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InChI
InChI=1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
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InChIKey
POPFMWWJOGLOIF-XWCQMRHXSA-N
CAS
1524-88-5
Physicochemical Property
logP
2.4987
Rotatable Bonds
2
Heavy Atom Count
31
Polar Areas
93.06
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 15209
ChEMBL ID
CHEMBL1201012
DrugBank ID
DB00846
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
Potency ~ 31622.8 nM
   TI
   LI
   LO
   TS
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000162 HeLa S3 Homo sapiens (Human)  2
1
IC50 = 4.447 nM
   TI
   LI
   LO
   TS
2
Ki = 2.021 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Flurandrenolide )
Drug Name Flurandrenolide
Company Watson Laboratories
Indication
Inflammation
Approved