General Information of the Compound
Compound ID
CP0075166
Compound Name
4-[6-ethyl-5-[[4-[(5R)-3-(oxan-4-yl)-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]methyl]pyridin-2-yl]oxybenzoic acid
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Structure
Formula
C34H40N4O5
Molecular Weight
584.717
Canonical SMILES
CCc1nc(Oc2ccc(cc2)C(O)=O)ccc1CN1CCC(CC1)N1[C@@H](CN(C2CCOCC2)C1=O)c1ccccc1
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InChI
InChI=1S/C34H40N4O5/c1-2-30-26(10-13-32(35-30)43-29-11-8-25(9-12-29)33(39)40)22-36-18-14-28(15-19-36)38-31(24-6-4-3-5-7-24)23-37(34(38)41)27-16-20-42-21-17-27/h3-13,27-28,31H,2,14-23H2,1H3,(H,39,40)/t31-/m0/s1
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InChIKey
FJAGYOZYOQUDEQ-HKBQPEDESA-N
Physicochemical Property
logP
5.7568
Rotatable Bonds
9
Heavy Atom Count
43
Polar Areas
95.44
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58835217
ChEMBL ID
CHEMBL2435856
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01508, C-C chemokine receptor type 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000131 HEK293-F Homo sapiens (Human)  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS