General Information of the Compound
Compound ID
CP0041509
Compound Name
7-hydroxy-2H-1-benzopyran-2-one
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Synonyms
2H-1-Benzopyran-2-one, 7-hydroxy-
60Z60NTL4G
7 HC
7-HC
7-Hydroxy-2H-1-benzopyran-2-one
7-Hydroxy-2H-chromen-2-one
7-Oxycoumarin
7-hydroxy-1-benzopyran-2-one
7-hydroxy-coumarin
7-hydroxychromen-2-one
7-hydroxycoumarin
7-hydroxycoumarine
7H-1-Benzopyran-7-one, 2-hydroxy-
93-35-6
AI3-38054
BRN 0127683
CCRIS 3591
CHEBI:27510
CHEMBL51628
Coumarin, 7-hydroxy-
EINECS 202-240-3
Hydrangin
Hydrangine
NSC 19790
NSC19790
Skimmetin
Skimmetine
UMBELLIFERONE
UNII-60Z60NTL4G
Umbelliferon
Umbelliferone
beta-Umbelliferone
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Structure
Formula
C9H6O3
Molecular Weight
162.144
Canonical SMILES
Oc1ccc2ccc(=O)oc2c1
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InChI
InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
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InChIKey
ORHBXUUXSCNDEV-UHFFFAOYSA-N
CAS
93-35-6
Physicochemical Property
logP
1.4986
Rotatable Bonds
0
Heavy Atom Count
12
Polar Areas
50.44
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
12

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5281426
SID: 87550949
ChEMBL ID
CHEMBL51628
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01430, 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 > 123350.1912 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 7-hydroxycoumarin )
Drug Name 7-hydroxycoumarin
Target(s)
Carbonic anhydrase IX (CA-IX)
Inhibitor
G1/S-specific cyclin-D1 (CCND1)
Inhibitor