Protein Information

General Information of the Protein

Protein ID	PT01011
Protein Name	Carbonic anhydrase 9
Secondarily Protein Name	Carbonate dehydratase IX Carbonic anhydrase IX Membrane antigen MN P54/58N Renal cell carcinoma-associated antigen G250 pMW1
Gene Name	CA9
Secondarily Gene Name	G250 MN
Sequence	MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Lyase
Function	Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). Show/Hide
Uniprot ID	Primary ID: Q16790 Secondarily ID: Q5T4R1 Show/Hide
Ensembl ID	ENSG00000107159
HGNC ID	HGNC:1383
Subcellular Location	Nucleus Nucleus Nucleolus Cell membrane Cell projection Microvillus membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000131 , HEK293-F

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0529090 Compound Info	4-chloro-2-(cyclohexylamino)-N-(3-hydroxypropyl)-5-sulfamoylbenzamide Show/Hide	C16H24ClN3O4S	1
1	Kd = 8.33 nM Bioactivity Info	TI LI LO TS
CP0459046 Compound Info	N-butyl-4-chloro-2-(cyclooctylamino)-5-sulfamoylbenzamide Show/Hide	C19H30ClN3O3S	1
1	Kd = 10 nM Bioactivity Info	TI LI LO TS
CP0396319 Compound Info	4-chloro-2-(cyclohexylamino)-N-(2-hydroxyethyl)-5-sulfamoylbenzamide Show/Hide	C15H22ClN3O4S	1
1	Kd = 20 nM Bioactivity Info	TI LI LO TS
CP0445936 Compound Info	N-butyl-4-chloro-2-(cyclohexylamino)-5-sulfamoylbenzamide Show/Hide	C17H26ClN3O3S	1
1	Kd = 20 nM Bioactivity Info	TI LI LO TS
CP0541268 Compound Info	N-benzyl-2-(benzylamino)-4-chloro-5-sulfamoylbenzamide Show/Hide	C21H20ClN3O3S	1
1	Kd = 25 nM Bioactivity Info	TI LI LO TS
CP0483097 Compound Info	2,4-dibromo-N-butyl-5-sulfamoylbenzamide Show/Hide	C11H14Br2N2O3S	1
1	Kd = 28.6 nM Bioactivity Info	TI LI LO TS
CP0396320 Compound Info	2-(benzylamino)-4-chloro-N-(3-hydroxypropyl)-5-sulfamoylbenzamide Show/Hide	C17H20ClN3O4S	1
1	Kd = 31.1 nM Bioactivity Info	TI LI LO TS
CP0482183 Compound Info	2-(benzylamino)-4-chloro-N-(2-methoxyethyl)-5-sulfamoylbenzamide Show/Hide	C17H20ClN3O4S	1
1	Kd = 33.3 nM Bioactivity Info	TI LI LO TS
CP0482182 Compound Info	2-(benzylamino)-N-butyl-4-chloro-5-sulfamoylbenzamide Show/Hide	C18H22ClN3O3S	1
1	Kd = 40 nM Bioactivity Info	TI LI LO TS
CP0548211 Compound Info	2-(benzylamino)-4-chloro-N-(2-hydroxyethyl)-5-sulfamoylbenzamide Show/Hide	C16H18ClN3O4S	1
1	Kd = 40 nM Bioactivity Info	TI LI LO TS
CP0557459 Compound Info	4-bromo-N-butyl-2-(cyclohexylamino)-5-sulfamoylbenzamide Show/Hide	C17H26BrN3O3S	1
1	Kd = 40 nM Bioactivity Info	TI LI LO TS
CP0471784 Compound Info	2,4-dichloro-N-(3-hydroxypropyl)-5-sulfamoylbenzamide Show/Hide	C10H12Cl2N2O4S	1
1	Kd = 50 nM Bioactivity Info	TI LI LO TS
CP0473662 Compound Info	N-butyl-2,4-dichloro-5-sulfamoylbenzamide Show/Hide	C11H14Cl2N2O3S	1
1	Kd = 50 nM Bioactivity Info	TI LI LO TS
CP0483096 Compound Info	2,4-dichloro-N-(2-methoxyethyl)-5-sulfamoylbenzamide Show/Hide	C10H12Cl2N2O4S	1
1	Kd = 71.4 nM Bioactivity Info	TI LI LO TS
CP0471755 Compound Info	N-benzyl-2,4-dichloro-5-sulfamoylbenzamide Show/Hide	C14H12Cl2N2O3S	1
1	Kd = 90.9 nM Bioactivity Info	TI LI LO TS
CP0427358 Compound Info	3-[(2,4-dichloro-5-sulfamoylbenzoyl)amino]propyl acetate Show/Hide	C12H14Cl2N2O5S	1
1	Kd = 125 nM Bioactivity Info	TI LI LO TS
CP0481940 Compound Info	2,4-dichloro-5-sulfamoylbenzamide Show/Hide	C7H6Cl2N2O3S	1
1	Kd = 132 nM Bioactivity Info	TI LI LO TS
CP0396322 Compound Info	methyl 4-[(2,4-dichloro-5-sulfamoylbenzoyl)amino]butanoate Show/Hide	C12H14Cl2N2O5S	1
1	Kd = 139 nM Bioactivity Info	TI LI LO TS
CP0429441 Compound Info	2,4-dibromo-N-(2-hydroxyethyl)-5-sulfamoylbenzamide Show/Hide	C9H10Br2N2O4S	1
1	Kd = 154 nM Bioactivity Info	TI LI LO TS
CP0450871 Compound Info	2,4-dichloro-5-(morpholine-4-carbonyl)benzenesulfonamide Show/Hide	C11H12Cl2N2O4S	1
1	Kd = 154 nM Bioactivity Info	TI LI LO TS
CP0396318 Compound Info	4-chloro-2-(cyclooctylamino)-5-sulfamoylbenzoic acid Show/Hide	C15H21ClN2O4S	1
1	Kd = 164 nM Bioactivity Info	TI LI LO TS
CP0445935 Compound Info	2,4-dichloro-N-(2-hydroxyethyl)-5-sulfamoylbenzamide Show/Hide	C9H10Cl2N2O4S	1
1	Kd = 167 nM Bioactivity Info	TI LI LO TS
CP0539803 Compound Info	2,4-dichloro-N-cyclohexyl-5-sulfamoylbenzamide Show/Hide	C13H16Cl2N2O3S	1
1	Kd = 250 nM Bioactivity Info	TI LI LO TS
CP0404141 Compound Info	4-[(2,4-dichloro-5-sulfamoylbenzoyl)amino]butanoic acid Show/Hide	C11H12Cl2N2O5S	1
1	Kd = 286 nM Bioactivity Info	TI LI LO TS
CP0481939 Compound Info	2,4-dibromo-5-sulfamoylbenzoic acid Show/Hide	C7H5Br2NO4S	1
1	Kd = 625 nM Bioactivity Info	TI LI LO TS
CP0284881 Compound Info	2,4-dichloro-5-sulfamoylbenzoic acid Show/Hide	C7H5Cl2NO4S	1
1	Kd = 667 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0034627 Compound Info	AZA Show/Hide	C4H6N4O3S2	81
1	IC50 = 2.58 nM
2	IC50 = 7.7 nM
3	IC50 = 7.72 nM
4	IC50 = 21 nM
5	IC50 = 25 nM
6	IC50 = 28 nM
7	IC50 = 30 nM
8	IC50 = 31 nM
9	IC50 = 32 nM
10	IC50 = 36.2 nM
11	IC50 = 36.7 nM
12	IC50 = 42.1 nM
13	IC50 = 44.3 nM
14	IC50 = 48.7 nM
15	IC50 = 52.5 nM
16	IC50 = 53.4 nM
17	IC50 = 54 nM
18	IC50 = 56.7 nM
19	IC50 = 65.2 nM
20	IC50 = 70.9 nM
21	IC50 = 73 nM
22	IC50 = 82 nM
23	IC50 = 87.2 nM
24	IC50 = 94 nM
25	IC50 = 123.6 nM
26	IC50 = 132 nM
27	IC50 = 174.8 nM
28	IC50 = 176.8 nM
29	IC50 = 183.3 nM
30	IC50 = 200.6 nM
31	IC50 = 208.1 nM
32	IC50 = 218.8 nM
33	IC50 = 236.1 nM
34	IC50 = 243.1 nM
35	IC50 = 286.5 nM
36	IC50 = 304.6 nM
37	IC50 = 318.6 nM
38	IC50 = 410.3 nM
39	IC50 = 622 nM
40	IC50 = 670.3 nM
41	IC50 = 680 nM
42	IC50 = 694.5 nM
43	IC50 = 700 nM
44	IC50 = 721 nM
45	IC50 = 735 nM
46	IC50 = 746.9 nM
47	IC50 = 763 nM
48	IC50 = 775 nM
49	IC50 = 903 nM
50	IC50 = 973 nM
51	IC50 = 999.8 nM
52	IC50 = 1024 nM
53	IC50 = 1165 nM
54	IC50 = 1294 nM
55	IC50 = 1297 nM
56	IC50 = 1513 nM
57	IC50 = 1520 nM
58	IC50 = 1524 nM
59	IC50 = 1764 nM
60	IC50 = 1997 nM
61	IC50 = 2134 nM
62	Kd < 5 nM
63	Kd = 6.7 nM
64	Kd = 14 nM
65	Kd = 20 nM
66	Kd = 22 nM
67	Kd = 50 nM
68	Ki = 0.06 nM
69	Ki = 5.6 nM
70	Ki = 16 nM
71	Ki = 20 nM
72	Ki = 25 nM
73	Ki = 25.1 nM
74	Ki = 25.2 nM
75	Ki = 25.3 nM
76	Ki = 25.4 nM
77	Ki = 25.7 nM
78	Ki = 25.8 nM
79	Ki = 26 nM
80	Ki = 30 nM
81	Ki = 5700 nM
CP0037494 Compound Info	(2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide Show/Hide	C10H16N2O4S3	2
1	IC50 = 52 nM
2	Ki = 52 nM
CP0157806 Compound Info	N-(1,1,3-trioxo-1,2-benzothiazol-5-yl)acetamide Show/Hide	C9H8N2O4S	1
1	Ki = 30.4 nM
CP0565046 Compound Info	3-bromo-N-(1,1,3-trioxo-1,2-benzothiazol-4-yl)benzamide Show/Hide	C14H9BrN2O4S	1
1	Ki = 31.2 nM
CP0434516 Compound Info	3-chloro-N-(1,1,3-trioxo-1,2-benzothiazol-5-yl)benzamide Show/Hide	C14H9ClN2O4S	1
1	Ki = 67.9 nM

Clinical Information about the Protein

Target 1 ( Carbonic anhydrase IX (CA-IX) )

Target Type	Clinical trial Target
Disease	3 Target-related Diseases				3
1	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
2	Breast cancer [ICD-11: 2C60-2C65]
3	Lymphoma [ICD-11: 2A80-2A86]
Clinical Trial Drug(s)	3 Clinical Trial Drugs				3
1	Curcumin	Drug Info	Phase 3	Solid tumour/cancer
2	Coumate	Drug Info	Phase 2	Breast cancer
3	INDISULAM	Drug Info	Phase 2	Lymphoma
Investigative Drug(s)	1 Investigative Drug				1
1	CL-5343	Drug Info	Investigative	Solid tumour/cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han