General Information of the Compound
Compound ID
CP0041478
Compound Name
3-isothiocyanatoprop-1-ene
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Synonyms
1-Propene, 3-isothiocyanato-
2-Propenyl isothiocyanate
3-Isothiocyanato-1-propene
3-isothiocyanatoprop-1-ene
57-06-7
AITC
ALLYL ISOTHIOCYANATE
ALLYLISOTHIOCYANATE
Allyl isosulfocyanate
Allyl isothiocyanate
Allyl mustard oil
Allyl sevenolum
Allylsenevol
Allylsenfoel
Allylsevenolum
Allyspol
Carbospol
Isothiocyanate d'allyle
Isothiocyanic acid all
MUSTARD OIL
Mustard seed oil
Oil Of mustard
Oils, mustard
Oleum sinapis
Oleum sinapis volatile
Redskin
Senf oel
Senfoel
Synthetic mustard oil
Volatile mustard oil
Volatile oil of mustard
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Structure
Formula
C4H5NS
Molecular Weight
99.158
Canonical SMILES
C=CCN=C=S
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InChI
InChI=1S/C4H5NS/c1-2-3-5-4-6/h2H,1,3H2
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InChIKey
ZOJBYZNEUISWFT-UHFFFAOYSA-N
CAS
58391-87-0
50978-48-8
57-06-7
50888-64-7
107231-30-1
Physicochemical Property
logP
1.2752
Rotatable Bonds
2
Heavy Atom Count
6
Polar Areas
12.36
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
6

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5971
SID: 14891411
ChEMBL ID
CHEMBL233248
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01234, Macrophage migration inhibitory factor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
Protein ID: PT02149, Transient receptor potential cation channel subfamily A member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000058 T-REx-293 Homo sapiens (Human)  6
1
EC50 = 398 nM
   TI
   LI
   LO
   TS
2
EC50 = 580 nM
   TI
   LI
   LO
   TS
3
EC50 = 5754.4 nM
   TI
   LI
   LO
   TS
4
EC50 = 10471.29 nM
   TI
   LI
   LO
   TS
5
EC50 = 12022.64 nM
   TI
   LI
   LO
   TS
6
EC50 = 22387.21 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T Homo sapiens (Human)  1
1
EC50 = 500 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 1120 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 1900 nM
2 EC50 = 8120 nM
3 EC50 = 33500 nM
Protein ID: PT02148, Transient receptor potential cation channel subfamily A member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  4
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
2
EC50 = 2500 nM
   TI
   LI
   LO
   TS
3
EC50 = 5813 nM
   TI
   LI
   LO
   TS
4
IC50 = 85900 nM
   TI
   LI
   LO
   TS
Protein ID: PT04242, Transient receptor potential cation channel subfamily A member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 22000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Allyl isothiocyanate )
Drug Name Allyl isothiocyanate
Indication
Acute or chronic pain
Approved