General Information of the Compound
Compound ID
CP0034062
Compound Name
(4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-(5-oxo-4-oxa-6-azaspiro[2.4]heptan-6-yl)spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione
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Structure
Formula
C23H22FN5O7
Molecular Weight
499.455
Canonical SMILES
C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2CC3(CC3)OC2=O)C(=O)NC(=O)NC1=O
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InChI
InChI=1S/C23H22FN5O7/c1-9-7-28-14-11(6-23(16(28)10(2)34-9)18(30)25-20(32)26-19(23)31)5-12-15(13(14)24)36-27-17(12)29-8-22(3-4-22)35-21(29)33/h5,9-10,16H,3-4,6-8H2,1-2H3,(H2,25,26,30,31,32)/t9-,10+,16-/m1/s1
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InChIKey
QKEDBKFDVRJINN-KCWFYHRYSA-N
Physicochemical Property
logP
1.3468
Rotatable Bonds
1
Heavy Atom Count
36
Polar Areas
143.31
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155547369
ChEMBL ID
CHEMBL4533341
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 40000 nM
   TI
   LI
   LO
   TS