General Information of the Compound
| Compound ID |
CP0031380
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| Compound Name |
CHEBI:85083
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| Synonyms |
1190307-88-0
2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester
AMMD00019
CHEBI:85083
CHEMBL1259059
EX-A389
GS 7977
GS-7977
GTPL7368
HSDB 8226
Hepcinat
Hepcvir
MolPort-028-720-482
PSI 7977
PSI-7977
Resof
SCHEMBL2010114
SOVALDI
Sofosbuvir (JAN/USAN)
Sofosbuvir (PSI-7977, GS-7977)
Sofosbuvir [USAN:INN]
Sofosbuvir(PSI-7977)
Sovaldi (TN)
SoviHep
UNII-WJ6CA3ZU8B
WJ6CA3ZU8B
isopropyl (2S)-2-[[[(2R,
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| Structure |
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| Formula |
C22H29FN3O9P
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| Molecular Weight |
529.458
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| Canonical SMILES |
CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1
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| InChI |
InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1
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| InChIKey |
TTZHDVOVKQGIBA-IQWMDFIBSA-N
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| CAS |
1190307-88-0
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00013, RNA-directed RNA polymerase
Cell-based Assay
Cell Viability or Cytotoxicity Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000057 | Vero | Chlorocebus sabaeus (Green monkey) | 1 |
| 1 |
CC50 = 360000 nM
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Clinical Information about the Compound