General Information of the Compound
Compound ID
CP0029575
Compound Name
4-[(2,6-dichlorobenzoyl)amino]-N-[1-[[3-(propanoylamino)phenyl]methyl]piperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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Structure
Formula
C28H29Cl2F3N6O5
Molecular Weight
657.477
Canonical SMILES
OC(=O)C(F)(F)F.CCC(=O)Nc1cccc(CN2CCC(CC2)NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)c1
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InChI
InChI=1S/C26H28Cl2N6O3.C2HF3O2/c1-2-22(35)30-18-6-3-5-16(13-18)15-34-11-9-17(10-12-34)31-26(37)24-21(14-29-33-24)32-25(36)23-19(27)7-4-8-20(23)28;3-2(4,5)1(6)7/h3-8,13-14,17H,2,9-12,15H2,1H3,(H,29,33)(H,30,35)(H,31,37)(H,32,36);(H,6,7)
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InChIKey
XQPWCQUMNDFXMA-UHFFFAOYSA-N
Physicochemical Property
logP
5.345
Rotatable Bonds
8
Heavy Atom Count
44
Polar Areas
156.52
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
6
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155532085
ChEMBL ID
CHEMBL4466865
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02179, Cyclin-dependent kinase 14
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 123 nM
   TI
   LI
   LO
   TS