General Information of the Protein
Protein ID
PT02179
Protein Name
Cyclin-dependent kinase 14
Secondarily
Protein Name
Cell division protein kinase 14
Serine/threonine-protein kinase PFTAIRE-1
Gene Name
CDK14
Secondarily
Gene Name
KIAA0834
PFTK1
Sequence
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase CDK family
>
CMGC protein kinase PFTAIRE
Function
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
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Uniprot ID
Primary ID:
O94921

Secondarily ID:
A4D1E6
A6NK51
A8WFP6
B4DHG5
B4DNM2
Q75N06
Q75N22
Q8N764
Q9H3D7
Q9UDR0
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Ensembl ID
ENSG00000058091
HGNC ID
HGNC:8883
Subcellular Location
Cell membrane
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0029567
 Compound Info 
4-[(2-chloro-6-methoxybenzoyl)amino]-N-[1-[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]sulfonylpiperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C31H35ClF3N7O8S
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0029570
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[1-[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]sulfonylpiperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C30H32Cl2F3N7O7S
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0029990
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[1-[[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]methyl]piperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C31H34Cl2F3N7O5
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0034077
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[1-[3-(prop-2-enoylamino)benzoyl]piperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C28H25Cl2F3N6O6
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0024531
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[1-[3-[[(E)-5-(dimethylamino)pent-2-enoyl]amino]phenyl]piperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C31H34Cl2F3N7O5
  1
1
IC50 = 1000 nM
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CP0030577
 Compound Info 
4-benzamido-N-[1-[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]sulfonylpiperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C30H34F3N7O7S
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0033254
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[4-[[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzoyl]amino]phenyl]-1H-pyrazole-3-carboxamide;2,2,2-trifluoroacetic acid
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C32H28Cl2F3N7O6
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0034078
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[1-[3-(prop-2-enoylamino)phenyl]sulfonylpiperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C27H25Cl2F3N6O7S
  1
1
IC50 = 1000 nM
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CP0638634
 Compound Info 
(E)-N-(1-(3-(4-(dimethylamino)but-2-enamido)phenylsulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide 2,2,2-trifluoroacetate
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C30H31Cl3F3N7O7S
  1
1
IC50 >= 500 nM
 Bioactivity Info 
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CP0023548
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[1-[3-(propanoylamino)phenyl]sulfonylpiperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C27H27Cl2F3N6O7S
  1
1
IC50 > 1000 nM
 Bioactivity Info 
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CP0023550
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[(3R)-1-[4-[[(E)-5-(dimethylamino)pent-2-enoyl]amino]phenyl]sulfonylpyrrolidin-3-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C30H32Cl2F3N7O7S
  1
1
IC50 > 1000 nM
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CP0023555
 Compound Info 
4-[(2,6-dimethoxybenzoyl)amino]-N-[1-[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]sulfonylpiperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C32H38F3N7O9S
  1
1
IC50 > 1000 nM
 Bioactivity Info 
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CP0029575
 Compound Info 
4-[(2,6-dichlorobenzoyl)amino]-N-[1-[[3-(propanoylamino)phenyl]methyl]piperidin-4-yl]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C28H29Cl2F3N6O5
  1
1
IC50 > 1000 nM
 Bioactivity Info 
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CP0032508
 Compound Info 
N-[1-[3-(prop-2-enoylamino)phenyl]sulfonylpiperidin-4-yl]-4-[(2,4,6-trimethoxybenzoyl)amino]-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
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C30H33F3N6O10S
  1
1
IC50 > 1000 nM
 Bioactivity Info 
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