General Information of the Compound
Compound ID
CP0019528
Compound Name
N-[(R)-cyclopropyl-(2-fluoropyridin-3-yl)methyl]-5-(6-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine
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Structure
Formula
C18H14F2N6O
Molecular Weight
368.347
Canonical SMILES
Fc1ccc2c(c[nH]c2n1)-c1nnc(N[C@H](C2CC2)c2cccnc2F)o1
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InChI
InChI=1S/C18H14F2N6O/c19-13-6-5-10-12(8-22-16(10)23-13)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-7-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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InChIKey
OIBUTVCVLWVDLE-CQSZACIVSA-N
Physicochemical Property
logP
3.8493
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
92.52
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 136245068
ChEMBL ID
CHEMBL3093079
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00985, Cell division cycle 7-related protein kinase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 250 nM
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