General Information of the Compound
Compound ID
CP0014115
Compound Name
(+/-)-thalidomide
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Synonyms
(+)-Thalidomide
(+-)-Thalidomide
(+/-)-THALIDOMIDE
(inverted question mark)-Thalidomide
2,6-Dioxo-3-phthalimidopiperidine
3-Phthalimidoglutarimide
50-35-1
Algosediv
Alpha-(N-Phthalimido)glutarimide
Alpha-N-Phthalylglutaramide
Alpha-Phthalimidoglutarimide
Asidon 3
Asmad
Asmadion
Asmaval
Bonbrain
Bonbrrin
Calmore
Calmorex
Celgene Brand of Thalidomide
Contergan
Corronarobetin
Distaval
Distaxal
Distoval
E-217
ENMD 0995
Ectiluran
Enterosediv
Gastrinide
Glupan
Glutanon
Grippex
Hippuzon
IN1061
Imida-lab
Imidan (peyta)
Imidene
Isomin
Kedavon
Kevadon
N-(2,6-Dioxo-3-piperidyl)phthalimide
N-Phthalimidoglutamic acid imide
N-Phthaloylglutamimide
N-Phthalyl-glutaminsaeure-imid
N-Phthalyl-glutaminsaeure-imid [German]
N-Phthalylglutamic acid imide
Neaufatin
Neosedyn
Neosydyn
Nerosedyn
Neufatin
Neurodyn
Neurosedin
Neurosedym
Neurosedyn
Nevrodyn
Nibrol
Noctosediv
Noxodyn
Pangul
Pantosediv
Poly-Giron
Polygripan
Predni-Sediv
Pro-Bam M
Pro-ban M
Profarmil
Psycholiquid
Psychotablets
Quetimid
Quietoplex
Sandormin
Sedalis
Sedalis sedi-lab
Sedimide
Sedin
Sedisperil
Sedoval
Shin-naito S
Shinnibrol
Sleepan
Slipro
Softenil
Softenon
Synovir
THALIDOMIDE (AIDS INITIATIVE)
Talargan
Talidomida
Talidomida [INN-Spanish]
Talidomide
Talidomide [DCIT]
Talimol
Talismol
Talizer
Telagan
Telargan
Telargean
Tensival
Thaled
Thaled (TN)
Thalidomide
Thalidomide (+ and-)
Thalidomide (JAN/USP/INN)
Thalidomide (soluble form)
Thalidomide Celgene
Thalidomide Pharmion
Thalidomide [USAN:INN:BAN]
Thalidomidum
Thalidomidum [INN-Latin]
Thalidomine USP26
Thalin
Thalinette
Thalomid
Thalomid (TM)
Thalomid (TN)
Thalomid, Thalidomide
Thalomide
Theophilcholine
Valgis
Valgraine
Yodomin
thalidomide
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Structure
Formula
C13H10N2O4
Molecular Weight
258.233
Canonical SMILES
O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
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InChI
InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
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InChIKey
UEJJHQNACJXSKW-UHFFFAOYSA-N
CAS
14088-68-7
50-35-1
731-40-8
841-67-8
Physicochemical Property
logP
0.0878
Rotatable Bonds
1
Heavy Atom Count
19
Polar Areas
83.55
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
19

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5426
SID: 14798889
ChEMBL ID
CHEMBL468
DrugBank ID
DB01041
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480
 Cell Line Info 
Homo sapiens (Human)  1
1
Potency ~ 562.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Thalidomide )
Drug Name Thalidomide
Indication
Multiple myeloma
Approved
Target(s)
Tumor necrosis factor (TNF)
 Target Info 
Inhibitor
Drug 2 ( Thalidomide )
Drug Name Thalidomide
Indication
Multiple myeloma
Approved
Coronavirus Disease 2019 (COVID-19)
Phase 2