General Information of the Compound
Compound ID
CP0011037
Compound Name
2,5-diphenyl-N-[1-(4-pyrimidin-2-ylpiperazin-1-yl)propan-2-yl]pyrazole-3-carboxamide
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Structure
Formula
C27H29N7O
Molecular Weight
467.577
Canonical SMILES
CC(CN1CCN(CC1)c1ncccn1)NC(=O)c1cc(nn1-c1ccccc1)-c1ccccc1
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InChI
InChI=1S/C27H29N7O/c1-21(20-32-15-17-33(18-16-32)27-28-13-8-14-29-27)30-26(35)25-19-24(22-9-4-2-5-10-22)31-34(25)23-11-6-3-7-12-23/h2-14,19,21H,15-18,20H2,1H3,(H,30,35)
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InChIKey
KHXPSURTKBYAGR-UHFFFAOYSA-N
Physicochemical Property
logP
3.2698
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
79.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46231351
ChEMBL ID
CHEMBL596814
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05900, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1000 nM
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