General Information of the Compound
Compound ID
CP0009664
Compound Name
ORMETOPRIM
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Structure
Formula
C14H18N4O2
Molecular Weight
274.324
Canonical SMILES
COc1cc(C)c(Cc2cnc(N)nc2N)cc1OC
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InChI
InChI=1S/C14H18N4O2/c1-8-4-11(19-2)12(20-3)6-9(8)5-10-7-17-14(16)18-13(10)15/h4,6-7H,5H2,1-3H3,(H4,15,16,17,18)
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InChIKey
KEEYRKYKLYARHO-UHFFFAOYSA-N
CAS
6981-18-6
Physicochemical Property
logP
1.55742
Rotatable Bonds
4
Heavy Atom Count
20
Polar Areas
96.28
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 23418
SID: 15222008
ChEMBL ID
CHEMBL494760
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05900, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS