General Information of the Compound
Compound ID
CP0008685
Compound Name
5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)-2-N-(oxan-4-yl)pyrimidine-2,4-diamine
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Structure
Formula
C19H25IN4O3
Molecular Weight
484.338
Canonical SMILES
COc1cc(C(C)C)c(Oc2cnc(NC3CCOCC3)nc2N)cc1I
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InChI
InChI=1S/C19H25IN4O3/c1-11(2)13-8-16(25-3)14(20)9-15(13)27-17-10-22-19(24-18(17)21)23-12-4-6-26-7-5-12/h8-12H,4-7H2,1-3H3,(H3,21,22,23,24)
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InChIKey
DOIRBVVZCMJEJL-UHFFFAOYSA-N
Physicochemical Property
logP
4.1786
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
91.52
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44573331
ChEMBL ID
CHEMBL493547
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05900, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 125.89 nM
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