General Information of the Compound
Compound ID
CP0004203
Compound Name
4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine
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Structure
Formula
C22H29ClN8
Molecular Weight
440.983
Canonical SMILES
CC(C)c1n[nH]c(Cl)c1-c1ccnc(Nc2ccc(cn2)N2CCC(CC2)N(C)C)n1
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InChI
InChI=1S/C22H29ClN8/c1-14(2)20-19(21(23)29-28-20)17-7-10-24-22(26-17)27-18-6-5-16(13-25-18)31-11-8-15(9-12-31)30(3)4/h5-7,10,13-15H,8-9,11-12H2,1-4H3,(H,28,29)(H,24,25,26,27)
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InChIKey
JKFGTURSEBTJIZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.3125
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
85.86
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49765254
SID: 103021557
ChEMBL ID
CHEMBL1272116
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01023, Cyclin-dependent kinase 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000182 JeKo-1 Homo sapiens (Human)  2
1
IC50 = 324 nM
   TI
   LI
   LO
   TS
2
IC50 = 365 nM
   TI
   LI
   LO
   TS