General Information of the Cell Line
Cell Line ID
CL000895
Cell Line Name
2008/MRP1
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0473
Tissue Information
Omentum
Disease
Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02516, Multidrug resistance-associated protein 1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0874272
 Compound Info 
2,2'-(4,4'-(3,6,9,12,15-pentaoxaheptadecane-1,17-diylbis(oxy))bis(4,1-phenylene))bis(7-methyl-4H-chromen-4-one)
   Show/Hide
C44H46O11
  1
1
Activity = 86 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0861780
 Compound Info 
2,2'-(4,4'-(3,6,9,12,15-pentaoxaheptadecane-1,17-diylbis(oxy))bis(4,1-phenylene))bis(6-methyl-4H-chromen-4-one)
   Show/Hide
C44H46O11
  1
1
Activity = 105 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0874271
 Compound Info 
2,2'-(4,4'-(3,6,9,12-tetraoxatetradecane-1,14-diylbis(oxy))bis(4,1-phenylene))bis(7-methyl-4H-chromen-4-one)
   Show/Hide
C42H42O10
  1
1
Activity = 133 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392216
 Compound Info 
7-[2-[2-[4-[3-[4-(7-fluoro-4-oxochromen-2-yl)phenoxy]propyl]triazol-1-yl]ethoxy]ethoxy]-2-phenylchromen-4-one
   Show/Hide
C39H32FN3O7
  1
1
EC50 = 53 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0381563
 Compound Info 
1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13,16-hexaoxahexadecane
   Show/Hide
C42H42O10
  3
1
EC50 = 73 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
Ki = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405360
 Compound Info 
7-[2-[benzyl-[[1-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]methyl]amino]ethoxy]-2-phenylchromen-4-one
   Show/Hide
C46H40N4O7
  1
1
EC50 = 78 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455369
 Compound Info 
7-[4-[1-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]butoxy]-2-phenylchromen-4-one
   Show/Hide
C40H35N3O7
  1
1
EC50 = 87 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0421418
 Compound Info 
7-[3-[1-[2-[2-[2-[4-(6-fluoro-4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]propoxy]-2-phenylchromen-4-one
   Show/Hide
C41H36FN3O8
  1
1
EC50 = 95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0394398
 Compound Info 
7-[2-[benzyl-[[1-[2-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl]amino]ethoxy]-2-phenylchromen-4-one
   Show/Hide
C48H44N4O8
  1
1
EC50 = 99 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392219
 Compound Info 
7-fluoro-2-[4-[3-[1-[2-[2-[2-[4-(6-fluoro-4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]propoxy]phenyl]chromen-4-one
   Show/Hide
C41H35F2N3O8
  1
1
EC50 = 103 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392220
 Compound Info 
6-methyl-2-[4-[4-[1-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]butoxy]phenyl]chromen-4-one
   Show/Hide
C41H37N3O7
  1
1
EC50 = 103 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392218
 Compound Info 
2-[4-[3-[1-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]propoxy]phenyl]chromen-4-one
   Show/Hide
C39H33N3O7
  1
1
EC50 = 113 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405491
 Compound Info 
2-[4-[2-[2-[2-[4-[3-[4-(7-fluoro-4-oxochromen-2-yl)phenoxy]propyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]-6-methylchromen-4-one
   Show/Hide
C42H38FN3O8
  1
1
EC50 = 121 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405492
 Compound Info 
6-methyl-2-[4-[4-[1-[2-[2-[2-[4-(6-methyl-4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]butoxy]phenyl]chromen-4-one
   Show/Hide
C44H43N3O8
  1
1
EC50 = 137 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0394401
 Compound Info 
7-fluoro-2-[4-[3-[1-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]propoxy]phenyl]chromen-4-one
   Show/Hide
C39H32FN3O7
  1
1
EC50 = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0394395
 Compound Info 
7-[3-[1-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]propoxy]-2-phenylchromen-4-one
   Show/Hide
C39H33N3O7
  1
1
EC50 = 151 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0394430
 Compound Info 
7-[2-[benzyl-[[1-[2-[2-[4-(6-fluoro-4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]methyl]amino]ethoxy]-2-phenylchromen-4-one
   Show/Hide
C46H39FN4O7
  1
1
EC50 = 155 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0437292
 Compound Info 
7-[2-[benzyl-[[1-[2-[2-[2-[4-(6-fluoro-4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl]amino]ethoxy]-2-phenylchromen-4-one
   Show/Hide
C48H43FN4O8
  1
1
EC50 = 156 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392215
 Compound Info 
6-methyl-2-[4-[4-[1-[2-[2-(4-oxo-2-phenylchromen-7-yl)oxyethoxy]ethyl]triazol-4-yl]butoxy]phenyl]chromen-4-one
   Show/Hide
C41H37N3O7
  1
1
EC50 = 175 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392714
 Compound Info 
2-[4-[2-[2-[2-[4-[2-(4-oxo-2-phenylchromen-7-yl)oxyethoxymethyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]-3-phenylmethoxychromen-4-one
   Show/Hide
C48H43N3O10
  1
1
EC50 = 193 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405489
 Compound Info 
7-fluoro-2-[4-[3-[1-[2-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]propoxy]phenyl]chromen-4-one
   Show/Hide
C41H36FN3O8
  1
1
EC50 = 208 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0438147
 Compound Info 
2-[4-[4-[1-[2-[2-[2-[4-(6-fluoro-4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]butoxy]phenyl]-6-methylchromen-4-one
   Show/Hide
C43H40FN3O8
  1
1
EC50 = 217 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426779
 Compound Info 
2-[4-[4-[1-[2-[2-[4-(6-fluoro-4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]butoxy]phenyl]-6-methylchromen-4-one
   Show/Hide
C41H36FN3O7
  1
1
EC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392213
 Compound Info 
7-[2-[[1-[2-[2-[4-(4-oxochromen-2-yl)phenoxy]ethoxy]ethyl]triazol-4-yl]methoxy]ethoxy]-2-phenylchromen-4-one
   Show/Hide
C39H33N3O8
  1
1
EC50 = 263 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392214
 Compound Info 
7-[3-[1-[2-[2-(4-oxo-2-phenylchromen-7-yl)oxyethoxy]ethyl]triazol-4-yl]propoxy]-2-phenylchromen-4-one
   Show/Hide
C39H33N3O7
  1
1
EC50 = 298 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0494143
 Compound Info 
methyl 3-[[2-[4-[2-[2-[2-[4-[[benzyl(2-hydroxyethyl)amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C42H44N4O9
  2
1
EC50 = 592 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0559073
 Compound Info 
methyl 3-[[2-[4-[2-[2-[4-[[benzyl(methyl)amino]methyl]triazol-1-yl]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C39H38N4O7
  2
1
EC50 = 681 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0487253
 Compound Info 
methyl 3-[[2-[4-[2-[2-[2-[4-[4-(4-formylphenoxy)butyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C43H43N3O10
  1
1
EC50 = 865 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0487252
 Compound Info 
methyl 3-[[2-[4-[4-(1-benzyltriazol-4-yl)butoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C37H33N3O6
  2
1
EC50 = 886 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0141589
 Compound Info 
3-((3S,6S)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-propionic acid tert-butyl ester
   Show/Hide
C26H35N3O5
  1
1
EC50 = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915258
 Compound Info 
tert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-7-oxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
   Show/Hide
C26H37N3O4
  2
1
EC50 = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 1950 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036382
 Compound Info 
CAS_52-53-9
   Show/Hide
C27H38N2O4
  3
1
EC50 = 1925 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 13200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
Ki = 13400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0078757
 Compound Info 
(E)-3-((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)(3-(dimethylamino)-3-oxopropylthio)methylthio)propanoic acid
   Show/Hide
C26H27ClN2O3S2
  1
1
EC50 = 19000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0487254
 Compound Info 
methyl 3-[[2-[4-[2-[2-[4-[(dibenzylamino)methyl]triazol-1-yl]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C45H42N4O7
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0527500
 Compound Info 
methyl 3-[[2-[4-[4-[1-[2-(2-hydroxyethoxy)ethyl]triazol-4-yl]butoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C34H35N3O8
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0527501
 Compound Info 
methyl 3-[[2-[4-[2-[2-[2-[4-[[benzyl(methyl)amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C41H42N4O8
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0527503
 Compound Info 
methyl 3-[[2-(4-hex-5-ynoxyphenyl)-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C30H26O6
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0531378
 Compound Info 
methyl 3-[[2-[4-[2-(2-azidoethoxy)ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C28H25N3O7
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0531379
 Compound Info 
methyl 3-[[2-[4-[2-[2-[2-[4-[2-(1,3-dioxoisoindol-2-yl)ethyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C42H38N4O10
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0531380
 Compound Info 
methyl 3-[[2-[4-[2-[2-[4-[2-(1,3-dioxoisoindol-2-yl)ethyl]triazol-1-yl]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C40H34N4O9
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0544327
 Compound Info 
methyl 3-[[2-[4-[2-[2-[4-(anilinomethyl)triazol-1-yl]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C37H34N4O7
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547453
 Compound Info 
methyl 3-[[2-[4-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C30H29N3O8
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0421254
 Compound Info 
methyl 3-[[2-[4-[2-[2-[4-[3-[1-[2-[2-[4-[3-[(3-methoxycarbonylphenyl)methoxy]-4-oxochromen-2-yl]phenoxy]ethoxy]ethyl]triazol-4-yl]phenyl]triazol-1-yl]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
   Show/Hide
C66H56N6O14
  1
1
EC50 > 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002490
 Compound Info 
1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis(oxidanyl)anthracene-9,10-dione;hydrochloride
   Show/Hide
C22H28N4O6
  1
1
IC50 = 27.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433749
 Compound Info 
[(2R,3S)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 4-fluoro-3-[(3,4,5-trimethoxybenzoyl)amino]benzoate
   Show/Hide
C37H38FNO12
  1
1
IC50 = 141 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400853
 Compound Info 
[(2R,3S)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3-[(3,4-dimethoxybenzoyl)amino]-4-fluorobenzoate
   Show/Hide
C36H36FNO11
  1
1
IC50 = 142 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0376150
 Compound Info 
[(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-chromen-3-yl] (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate
   Show/Hide
C32H36O11
  1
1
IC50 = 322 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0376151
 Compound Info 
[(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 4-fluoro-3-[(3,4,5-trimethoxybenzoyl)amino]benzoate
   Show/Hide
C37H38FNO12
  1
1
IC50 = 418 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0376714
 Compound Info 
[(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3-[(3,4-dimethoxybenzoyl)amino]-4-fluorobenzoate
   Show/Hide
C36H36FNO11
  1
1
IC50 = 434 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0060431
 Compound Info 
2,4-diaminofuro[2,3-d]pyrimidine, 10
   Show/Hide
 C18H20N4O2  1
1
IC50 > 500000 nM
   TI
   LI
   LO
   TS
CP0151567
 Compound Info 
2,4-diaminofuro[2,3-d]pyrimidine, 9
   Show/Hide
 C18H22N4O2  1
1
IC50 > 500000 nM
   TI
   LI
   LO
   TS
CP0861780
 Compound Info 
2,2'-(4,4'-(3,6,9,12,15-pentaoxaheptadecane-1,17-diylbis(oxy))bis(4,1-phenylene))bis(6-methyl-4H-chromen-4-one)
   Show/Hide
 C44H46O11  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0874271
 Compound Info 
2,2'-(4,4'-(3,6,9,12-tetraoxatetradecane-1,14-diylbis(oxy))bis(4,1-phenylene))bis(7-methyl-4H-chromen-4-one)
   Show/Hide
 C42H42O10  2
1
IC50 = 53300 nM
   TI
   LI
   LO
   TS
2
IC50 = 60600 nM
   TI
   LI
   LO
   TS
CP0874272
 Compound Info 
2,2'-(4,4'-(3,6,9,12,15-pentaoxaheptadecane-1,17-diylbis(oxy))bis(4,1-phenylene))bis(7-methyl-4H-chromen-4-one)
   Show/Hide
 C44H46O11  1
1
IC50 = 10200 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Omentum)
Cell Line Name Organism Disease
OV-2008
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical squamous cell carcinoma
ME-180
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical squamous cell carcinoma
PC-2 [Human pancreatic carcinoma China]
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma