General Information of the Cell Line
Cell Line ID
CL000403
Cell Line Name
CAL-33
Synonyms
Cal-33
CAL 33
CAL33
Centre Antoine Lacassagne-33
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1108
Tissue Information
Tongue
Disease
Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01503, Signal transducer and activator of transcription 3
 Protein Info 
Compound ID Compound Name Compound Formula
CP0163405
 Compound Info 
US9211296, Table 7, Compd: 9
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C18H23N5
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0217024
 Compound Info 
6-(4-methoxyphenyl)-7-propan-2-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C20H22N6OS
  1
1
IC50 = 2200 nM
 Bioactivity Info 
   TI
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CP0551484
 Compound Info 
5-benzyl-2-[(6-ethoxy-4-methylquinazolin-2-yl)amino]-4-methyl-1H-pyrimidin-6-one
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C23H23N5O2
  1
1
IC50 = 2700 nM
 Bioactivity Info 
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CP0406147
 Compound Info 
2-[(6-ethoxy-4-methylquinazolin-2-yl)amino]-4-phenyl-1H-pyrimidin-6-one
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C21H19N5O2
  1
1
IC50 = 3400 nM
 Bioactivity Info 
   TI
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CP0181456
 Compound Info 
7-methyl-6-phenyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C20H16N6S
  1
1
IC50 = 3400 nM
 Bioactivity Info 
   TI
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CP0105990
 Compound Info 
6-(4-methoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C20H16N6OS
  1
1
IC50 = 3700 nM
 Bioactivity Info 
   TI
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CP0133758
 Compound Info 
3-[3-(4-fluorophenyl)-1H-pyrazol-5-yl]-7-methyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C20H15FN6S
  1
1
IC50 = 3800 nM
 Bioactivity Info 
   TI
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CP0181458
 Compound Info 
6-(3,4-dichlorophenyl)-7-(2-methylpropyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C20H20Cl2N6S
  1
1
IC50 = 4100 nM
 Bioactivity Info 
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CP0307074
 Compound Info 
3-[3-(4-fluorophenyl)-1H-pyrazol-5-yl]-6-(4-methoxyphenyl)-7-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C21H17FN6OS
  1
1
IC50 = 4200 nM
 Bioactivity Info 
   TI
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CP0133759
 Compound Info 
6-(3,4-dichlorophenyl)-7-propan-2-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C19H18Cl2N6S
  1
1
IC50 = 4400 nM
 Bioactivity Info 
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CP0413418
 Compound Info 
4-methyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]-1H-pyrimidin-6-one
   Show/Hide
C16H17N5O
  1
1
IC50 = 5000 nM
 Bioactivity Info 
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CP0307076
 Compound Info 
6-(4-methoxyphenyl)-7-(2-methylpropyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C24H24N6OS
  1
1
IC50 = 5100 nM
 Bioactivity Info 
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CP0406344
 Compound Info 
6-(3-chlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C19H13ClN6S
  1
1
IC50 = 5600 nM
 Bioactivity Info 
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CP0147464
 Compound Info 
4,5-dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]-1H-pyrimidin-6-one
   Show/Hide
C17H19N5O
  1
1
IC50 = 6400 nM
 Bioactivity Info 
   TI
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CP0230036
 Compound Info 
6-(3,4-dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C16H12Cl2N6S
  1
1
IC50 = 6800 nM
 Bioactivity Info 
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CP0475784
 Compound Info 
6-(3,4-dichlorophenyl)-3-[3-(4-fluorophenyl)-1H-pyrazol-5-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C19H11Cl2FN6S
  1
1
IC50 = 7500 nM
 Bioactivity Info 
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CP0551140
 Compound Info 
7-benzyl-6-(3,4-dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C23H18Cl2N6S
  1
1
IC50 = 7500 nM
 Bioactivity Info 
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CP0537674
 Compound Info 
4,6-dimethyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
   Show/Hide
C17H21N5
  1
1
IC50 = 7900 nM
 Bioactivity Info 
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CP0040848
 Compound Info 
6-(3,4-dichlorophenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C17H14Cl2N6S
  1
1
IC50 = 8200 nM
 Bioactivity Info 
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CP0181455
 Compound Info 
6-(4-methoxyphenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C18H18N6OS
  1
1
IC50 = 9100 nM
 Bioactivity Info 
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CP0054499
 Compound Info 
6-(4-Chloro-phenyl)-3-(5-phenyl-2H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C19H13ClN6S
  1
1
IC50 = 9600 nM
 Bioactivity Info 
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CP0379146
 Compound Info 
4,5-dimethyl-2-[(4,6,7-trimethylquinazolin-2-yl)amino]-1H-pyrimidin-6-one
   Show/Hide
C17H19N5O
  1
1
IC50 = 10400 nM
 Bioactivity Info 
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CP0379145
 Compound Info 
2-[(4,7-dimethylquinazolin-2-yl)amino]-4,5-dimethyl-1H-pyrimidin-6-one
   Show/Hide
C16H17N5O
  1
1
IC50 = 10500 nM
 Bioactivity Info 
   TI
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CP0217011
 Compound Info 
6-(5-chlorothiophen-2-yl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C14H11ClN6S2
  1
1
IC50 = 11000 nM
 Bioactivity Info 
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CP0515356
 Compound Info 
1,4-dioxane;6-phenyl-2-[(4,6,8-trimethyl-2-quinazolinyl)amino]-1H-pyrimidin-4-one
   Show/Hide
C21H19N5O
  1
1
IC50 = 11200 nM
 Bioactivity Info 
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CP0537688
 Compound Info 
2-[(6-ethoxy-4-methylquinazolin-2-yl)amino]-4,5-dimethyl-1H-pyrimidin-6-one
   Show/Hide
C17H19N5O2
  1
1
IC50 = 11700 nM
 Bioactivity Info 
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CP0379141
 Compound Info 
2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-4-phenyl-1H-pyrimidin-6-one
   Show/Hide
C20H15N5O3
  1
1
IC50 = 13000 nM
 Bioactivity Info 
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CP0551483
 Compound Info 
4-methyl-5-prop-2-enyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]-1H-pyrimidin-6-one
   Show/Hide
C19H21N5O
  1
1
IC50 = 14300 nM
 Bioactivity Info 
   TI
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CP0507002
 Compound Info 
3-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]-6-(3,4-dichlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C19H11Cl3N6S
  1
1
IC50 = 14500 nM
 Bioactivity Info 
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CP0520612
 Compound Info 
6-(3,4-dichlorophenyl)-3-(4,5,6,7-tetrahydro-1H-indazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C17H14Cl2N6S
  1
1
IC50 = 15500 nM
 Bioactivity Info 
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CP0152343
 Compound Info 
6-ethoxy-4-methyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
   Show/Hide
C18H23N5O
  1
1
IC50 = 15700 nM
 Bioactivity Info 
   TI
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CP0300521
 Compound Info 
6-(4-methoxyphenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C17H16N6OS
  1
1
IC50 = 17900 nM
 Bioactivity Info 
   TI
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CP0040849
 Compound Info 
6-(3,4-dichlorophenyl)-7,7-dimethyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C18H16Cl2N6S
  1
1
IC50 = 18600 nM
 Bioactivity Info 
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CP0520594
 Compound Info 
2-[(4,7-dimethylquinazolin-2-yl)amino]-4-methyl-1H-pyrimidin-6-one
   Show/Hide
C15H15N5O
  1
1
IC50 = 19100 nM
 Bioactivity Info 
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CP0217026
 Compound Info 
2-[6-(4-methoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]ethanamine
   Show/Hide
C22H21N7OS
  1
1
IC50 > 20000 nM
 Bioactivity Info 
   TI
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CP0232354
 Compound Info 
7-ethoxy-4-methyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
   Show/Hide
C18H23N5O
  1
1
IC50 = 20700 nM
 Bioactivity Info 
   TI
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CP0181454
 Compound Info 
6-phenyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C16H14N6S
  1
1
IC50 = 21200 nM
 Bioactivity Info 
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CP0240411
 Compound Info 
6-(3-chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C16H13ClN6S
  1
1
IC50 = 21200 nM
 Bioactivity Info 
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CP0406148
 Compound Info 
4-methyl-2-[(4,6,7-trimethylquinazolin-2-yl)amino]-1H-pyrimidin-6-one
   Show/Hide
C16H17N5O
  1
1
IC50 = 24700 nM
 Bioactivity Info 
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CP0054497
 Compound Info 
6-(4-chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C16H13ClN6S
  1
1
IC50 = 26800 nM
 Bioactivity Info 
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CP0240412
 Compound Info 
US10618914, Compound 7b
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C19H14N6S
  1
1
IC50 = 27000 nM
 Bioactivity Info 
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CP0379139
 Compound Info 
4-methyl-N-phenylquinazolin-2-amine
   Show/Hide
C15H13N3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0379140
 Compound Info 
N-[2-(1H-indol-3-yl)ethyl]-4-methylquinazolin-2-amine
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C19H18N4
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0379142
 Compound Info 
4-methyl-N-(2-morpholin-4-ylethyl)quinazolin-2-amine
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C15H20N4O
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0379143
 Compound Info 
N-cyclohexyl-4-methylquinazolin-2-amine
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C15H19N3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0379467
 Compound Info 
N-benzyl-4-methylquinazolin-2-amine
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C16H15N3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0413417
 Compound Info 
4-methyl-N-(naphthalen-1-ylmethyl)quinazolin-2-amine
   Show/Hide
C20H17N3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0413420
 Compound Info 
4-methyl-N-[(5-methylfuran-2-yl)methyl]quinazolin-2-amine
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C15H15N3O
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
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CP0413421
 Compound Info 
4-methyl-N-pyridin-2-ylquinazolin-2-amine
   Show/Hide
C14H12N4
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0553419
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-4-methylquinazolin-2-amine
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C17H15N3O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0300537
 Compound Info 
6-cyclohexyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C16H20N6S
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0300520
 Compound Info 
6-(3,4-dichlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C19H12Cl2N6S
  1
1
IC50 = 31200 nM
 Bioactivity Info 
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CP0379468
 Compound Info 
CS115
   Show/Hide
C15H15N5O2
  1
1
IC50 = 33900 nM
 Bioactivity Info 
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CP0379144
 Compound Info 
5-benzyl-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-4-methyl-1H-pyrimidin-6-one
   Show/Hide
C22H21N5O2
  1
1
IC50 = 34700 nM
 Bioactivity Info 
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CP0380898
 Compound Info 
2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-4-methyl-1H-pyrimidin-6-one
   Show/Hide
C15H15N5O2
  1
1
IC50 = 34900 nM
 Bioactivity Info 
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CP0380897
 Compound Info 
2-[(6-ethoxy-4-methylquinazolin-2-yl)amino]-4-methyl-1H-pyrimidin-6-one
   Show/Hide
C16H17N5O2
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0406149
 Compound Info 
4-methyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-one
   Show/Hide
C15H13N5O3
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0413419
 Compound Info 
5-benzyl-4-methyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-one
   Show/Hide
C22H19N5O3
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0553659
 Compound Info 
4,5-dimethyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-one
   Show/Hide
C16H15N5O3
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0105991
 Compound Info 
3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C13H10N6S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0217009
 Compound Info 
6-pyridin-4-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C15H13N7S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0240413
 Compound Info 
3-(3-phenyl-1H-pyrazol-5-yl)-6-pyridin-4-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C18H13N7S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0300536
 Compound Info 
US10618914, Compound 12b
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C14H12N6S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0350267
 Compound Info 
6-cyclohexyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
   Show/Hide
C19H20N6S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0350268
 Compound Info 
7-(2-methoxyethyl)-6-(4-methoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C23H22N6O2S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0350361
 Compound Info 
6-(5-chlorothiophen-2-yl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C17H11ClN6S2
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0447503
 Compound Info 
6-(4-methoxyphenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C17H18N6OS
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0447505
 Compound Info 
1-[6-(4-methoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-6,7-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-5-yl]ethanone
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C22H20N6O2S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0509881
 Compound Info 
3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C10H10N6S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0551157
 Compound Info 
6-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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C11H12N6S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT02212, Transcription factor ISGF-3 components p91/p84
 Protein Info 
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Tongue)
Cell Line Name Organism Disease
CAL-27
 Cell Line Info 
Homo sapiens (Human) Tongue adenosquamous carcinoma
HN-5
 Cell Line Info 
Homo sapiens (Human) Tongue squamous cell carcinoma
H103
 Cell Line Info 
Homo sapiens (Human) Tongue squamous cell carcinoma