General Information of the Cell Line
Cell Line ID
CL000369
Cell Line Name
P388/S
Synonyms
p388/s
P388S
P388 sensitive
P388 leukemia-sensitive
Category
Cancer cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_D640
Disease
Mouse lymphoma (NCIt: C21602)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT03467, DNA topoisomerase 1
Compound ID Compound Name Compound Formula
CP0224328
13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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C29H28N4O11
 1
1
EC50 = 1.5 nM
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CP0264632
2,10-Dihydroxy-6-[(3-hydroxybenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H28N4O11
 1
1
EC50 = 23 nM
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CP0163461
2,10-Dihydroxy-6-{[2-(hydroxymethyl)benzyl]amino}-13-(beta-Dglucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C34H30N4O11
 1
1
EC50 = 24 nM
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CP0036990
2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-2-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 = 73 nM
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CP0178369
6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H28N4O10
 1
1
EC50 = 80 nM
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CP0333357
2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-3-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 = 90 nM
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CP0316909
2,10-Dihydroxy-6-({[2-(hydroxymethyl)pyridin-4-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 = 100 nM
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CP0280882
2,10-Dihydroxy-6-[(4-hydroxybenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H28N4O11
 1
1
EC50 = 120 nM
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CP0316908
2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-2-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 = 120 nM
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CP0091014
2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-3-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 = 130 nM
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CP0199012
2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-4-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 = 130 nM
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CP0237965
2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-2-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 = 160 nM
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CP0288971
6-[(2-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C31H26N4O11
 1
1
EC50 = 180 nM
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CP0264635
2,10-Dihydroxy-6-[(pyrazin-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C31H26N6O10
 1
1
EC50 = 210 nM
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CP0333355
2,10-Dihydroxy-6-{[3-(hydroxymethyl)benzyl]amino}-13-(beta-Dglucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C34H30N4O11
 1
1
EC50 = 220 nM
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CP0269238
2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-2-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 = 400 nM
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CP0036989
2,10-Dihydroxy-6-[(pyridin-4-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C32H27N5O10
 1
1
EC50 = 420 nM
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CP0330921
6-[(3-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C31H26N4O11
 1
1
EC50 = 470 nM
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CP0330922
2,10-Dihydroxy-6-{[4-(hydroxymethyl)benzyl]amino}-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C34H30N4O11
 1
1
EC50 = 600 nM
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CP0274381
2,10-Dihydroxy-6-[(pyridin-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C32H27N5O10
 1
1
EC50 = 800 nM
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CP0092152
2,10-Dihydroxy-6-[(4-cyanobenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C34H27N5O10
 1
1
EC50 = 1700 nM
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CP0269237
2,10-Dihydroxy-6-[(quinolin-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C36H29N5O10
 1
1
EC50 = 1800 nM
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CP0333361
2,10-Dihydroxy-6-[(4-nitrolbenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H27N5O12
 1
1
EC50 = 6000 nM
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CP0333356
2,10-Dihydroxy-6-[(1H-pyrrol-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C31H27N5O10
 1
1
EC50 = 6500 nM
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CP0199009
2,10-Dihydroxy-6-[(quinolin-4-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C36H29N5O10
 1
1
EC50 = 10000 nM
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CP0199011
2,10-Dihydroxy-6-[(4-bromobenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H27BrN4O10
 1
1
EC50 = 10000 nM
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CP0221706
2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-3-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11
 1
1
EC50 > 10000 nM
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CP0236020
2,10-Dihydroxy-6-[(pyridin-3-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C32H27N5O10
 1
1
EC50 > 10000 nM
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CP0311569
2,10-Dihydroxy-6-[(quinolin-3-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C36H29N5O10
 1
1
EC50 > 10000 nM
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CP0333359
2,10-Dihydroxy-6-[(4-methylbenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C34H30N4O10
 1
1
EC50 > 10000 nM
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Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0036989
2,10-Dihydroxy-6-[(pyridin-4-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C32H27N5O10  1
1
IC50 = 0.48 nM
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CP0091014
2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-3-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11  1
1
IC50 = 0.49 nM
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CP0163461
2,10-Dihydroxy-6-{[2-(hydroxymethyl)benzyl]amino}-13-(beta-Dglucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C34H30N4O11  1
1
IC50 = 1.3 nM
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CP0199009
2,10-Dihydroxy-6-[(quinolin-4-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C36H29N5O10  1
1
IC50 = 1.8 nM
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CP0199012
2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-4-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11  1
1
IC50 = 0.28 nM
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CP0221706
2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-3-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11  1
1
IC50 = 0.33 nM
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CP0236020
2,10-Dihydroxy-6-[(pyridin-3-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C32H27N5O10  1
1
IC50 = 0.48 nM
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CP0237965
2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-2-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11  1
1
IC50 = 0.46 nM
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CP0264632
2,10-Dihydroxy-6-[(3-hydroxybenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H28N4O11  1
1
IC50 = 0.9 nM
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CP0269237
2,10-Dihydroxy-6-[(quinolin-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C36H29N5O10  1
1
IC50 = 4.8 nM
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CP0269238
2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-2-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11  1
1
IC50 = 0.4 nM
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CP0274381
2,10-Dihydroxy-6-[(pyridin-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C32H27N5O10  1
1
IC50 = 0.59 nM
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CP0280882
2,10-Dihydroxy-6-[(4-hydroxybenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H28N4O11  1
1
IC50 = 1.1 nM
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CP0288971
6-[(2-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C31H26N4O11  1
1
IC50 = 1.5 nM
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CP0333356
2,10-Dihydroxy-6-[(1H-pyrrol-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C31H27N5O10  1
1
IC50 = 0.77 nM
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CP0333357
2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-3-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H29N5O11  1
1
IC50 = 0.98 nM
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CP0333359
2,10-Dihydroxy-6-[(4-methylbenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C34H30N4O10  1
1
IC50 = 58 nM
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CP0333361
2,10-Dihydroxy-6-[(4-nitrolbenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
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C33H27N5O12  1
1
IC50 = 21 nM
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Protein family and CMB statistics Related to the Cell Line