Brief Information of the Cell Line and Protein
Cell Line ID: CL000870 , HEK-Blue Null1-v
Category Transformed cell line
Organism
Homo sapiens (Human)
Protein ID: PT03343 , Toll-like receptor 4
Gene Name TLR4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID O00206
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000870  Protein ID: PT03343
 
Compound ID Compound Name Compound Formula
CP0291589
6-(2-Chloro-4-fluoro-phenylsulfamoyl)-cyclohex-1-enecarboxylic acid ethyl ester
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C15H17ClFNO4S
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0575303
ethyl 6-[(2-chloro-4-fluorophenyl)-prop-2-ynylsulfamoyl]cyclohexene-1-carboxylate
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C18H19ClFNO4S
 1
1
IC50 = 334 nM
   TI
   LI
   LO
   TS
CP0125619
(NE)-N-[1-(6-methoxy-1,3-benzoxazol-2-yl)-2-(4-methoxyphenyl)ethylidene]hydroxylamine
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C17H16N2O4
 1
1
IC50 = 540 nM
   TI
   LI
   LO
   TS
CP0204776
ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate
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C15H17ClFNO4S
 1
1
IC50 = 680 nM
   TI
   LI
   LO
   TS
CP0243824
ethyl 6-[(2-chloro-4-fluorophenyl)-[(4-nitrophenyl)methyl]sulfamoyl]cyclohexene-1-carboxylate
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C22H22ClFN2O6S
 1
1
IC50 = 1785 nM
   TI
   LI
   LO
   TS
CP0127890
ethyl 6-[(2-chloro-4-fluorophenyl)-[(4-nitrophenyl)methoxycarbonyl]sulfamoyl]cyclohexene-1-carboxylate
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C23H22ClFN2O8S
 1
1
IC50 = 2701 nM
   TI
   LI
   LO
   TS
CP0423195
ethyl 6-[(2-chloro-4-fluorophenyl)-prop-2-ynoxycarbonylsulfamoyl]cyclohexene-1-carboxylate
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C19H19ClFNO6S
 1
1
IC50 = 3897 nM
   TI
   LI
   LO
   TS
CP0323991
(NE)-N-[1-(6-chloro-1,3-benzoxazol-2-yl)-2-(4-methoxyphenyl)ethylidene]hydroxylamine
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C16H13ClN2O3
 1
1
IC50 = 5420 nM
   TI
   LI
   LO
   TS
CP0566982
1-(9H-carbazol-4-yloxy)-3-(9H-fluoren-3-ylamino)propan-2-ol
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C28H24N2O2
 1
1
IC50 = 12390 nM
   TI
   LI
   LO
   TS
CP0389205
1-(9H-carbazol-4-yloxy)-3-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]propan-2-ol
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C29H31ClN4O2
 1
1
IC50 = 12450 nM
   TI
   LI
   LO
   TS
CP0481953
1-(9H-carbazol-4-yloxy)-3-[[1-[(4-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]propan-2-ol
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C29H31ClN4O2
 1
1
IC50 = 13640 nM
   TI
   LI
   LO
   TS
CP0388427
2-[4-[2-(3,4-dimethoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
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C25H33N3O2
 1
1
IC50 = 14970 nM
   TI
   LI
   LO
   TS
CP0388424
2-[4-[2-(3,4-dimethoxyphenyl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
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C27H37N3O2
 1
1
IC50 = 15100 nM
   TI
   LI
   LO
   TS
CP0909025
4-(9H-carbazol-4-yloxy)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)butan-2-ol
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C30H33ClN4O2
 1
1
IC50 = 15110 nM
   TI
   LI
   LO
   TS
CP0534161
4-(4-tert-butylphenoxy)-1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]butan-2-ol
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C28H38ClN3O2
 1
1
IC50 = 16680 nM
   TI
   LI
   LO
   TS
CP0529325
(NE)-N-[1-(6-methyl-1,3-benzoxazol-2-yl)-2-phenylethylidene]hydroxylamine
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C16H14N2O2
 1
1
IC50 = 19250 nM
   TI
   LI
   LO
   TS
CP0486046
[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-5-chlorophenyl]-phenylmethanone
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C28H23ClN2O3
 1
1
IC50 = 21120 nM
   TI
   LI
   LO
   TS
CP0408552
1-(9H-carbazol-4-yloxy)-3-(4-phenylanilino)propan-2-ol
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C27H24N2O2
 1
1
IC50 = 21710 nM
   TI
   LI
   LO
   TS
CP0482590
1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-propylphenoxy)butan-2-ol
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C27H36ClN3O2
 1
1
IC50 = 24680 nM
   TI
   LI
   LO
   TS
CP0416497
[(E)-1-(1,3-benzoxazol-2-yl)ethylideneamino] 2-methoxybenzoate
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C17H14N2O4
 1
1
IC50 = 25900 nM
   TI
   LI
   LO
   TS
CP0396348
1-[[1-[(4-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-ethoxyphenoxy)butan-2-ol
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C26H34ClN3O3
 1
1
IC50 = 25920 nM
   TI
   LI
   LO
   TS
CP0482180
1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-ethylphenoxy)butan-2-ol
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C26H34ClN3O2
 1
1
IC50 = 26020 nM
   TI
   LI
   LO
   TS
CP0561779
1-(9H-carbazol-4-yloxy)-3-(naphthalen-2-ylamino)propan-2-ol
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C25H22N2O2
 1
1
IC50 = 28530 nM
   TI
   LI
   LO
   TS
CP0564177
1-[(1-benzyl-3,5-dimethylpyrazol-4-yl)methyl-methylamino]-3-(9H-carbazol-4-yloxy)propan-2-ol
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C29H32N4O2
 1
1
IC50 = 31540 nM
   TI
   LI
   LO
   TS
CP0041757
1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
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C24H26N2O4
 1
1
IC50 = 32220 nM
   TI
   LI
   LO
   TS
CP0396349
4-(9H-carbazol-4-yloxy)-1-[2-(2-methoxyphenoxy)ethylamino]butan-2-ol
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C25H28N2O4
 1
1
IC50 = 32550 nM
   TI
   LI
   LO
   TS
CP0073822
1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-3-(4-ethoxyphenoxy)propan-2-ol
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C25H32ClN3O3
 1
1
IC50 = 34170 nM
   TI
   LI
   LO
   TS
CP0411526
1-(9H-carbazol-4-yloxy)-3-[[1-[(2-fluorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]propan-2-ol
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C29H31FN4O2
 1
1
IC50 = 34640 nM
   TI
   LI
   LO
   TS
CP0189470
(NE)-N-[2-(4-fluorophenyl)-1-(5-methyl-1,3-benzoxazol-2-yl)ethylidene]hydroxylamine
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C16H13FN2O2
 1
1
IC50 = 45650 nM
   TI
   LI
   LO
   TS
CP0411525
1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-methylphenoxy)butan-2-ol
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C25H32ClN3O2
 1
1
IC50 = 51540 nM
   TI
   LI
   LO
   TS
CP0569202
1-[[3,5-dimethyl-1-[(2-methylphenyl)methyl]pyrazol-4-yl]methyl-methylamino]-4-(4-ethoxyphenoxy)butan-2-ol
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C27H37N3O3
 1
1
IC50 = 54600 nM
   TI
   LI
   LO
   TS
CP0545855
1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-fluorophenoxy)butan-2-ol
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C24H29ClFN3O2
 1
1
IC50 = 55390 nM
   TI
   LI
   LO
   TS