General Information of the Compound
Compound ID
CP0482180
Compound Name
1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-ethylphenoxy)butan-2-ol
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Structure
Formula
C26H34ClN3O2
Molecular Weight
456.03
Canonical SMILES
CCc1ccc(OCCC(O)CN(C)Cc2c(C)nn(Cc3ccccc3Cl)c2C)cc1
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InChI
InChI=1S/C26H34ClN3O2/c1-5-21-10-12-24(13-11-21)32-15-14-23(31)17-29(4)18-25-19(2)28-30(20(25)3)16-22-8-6-7-9-26(22)27/h6-13,23,31H,5,14-18H2,1-4H3
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InChIKey
ZFVOERMZYIZKHZ-UHFFFAOYSA-N
Physicochemical Property
logP
5.02584
Rotatable Bonds
11
Heavy Atom Count
32
Polar Areas
50.52
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145950641
ChEMBL ID
CHEMBL4174733
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03343, Toll-like receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000870 HEK-Blue Null1-v Homo sapiens (Human)  1
1
IC50 = 26020 nM
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