General Information of the Compound
Compound ID
CP0125619
Compound Name
(NE)-N-[1-(6-methoxy-1,3-benzoxazol-2-yl)-2-(4-methoxyphenyl)ethylidene]hydroxylamine
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Structure
Formula
C17H16N2O4
Molecular Weight
312.325
Canonical SMILES
COc1ccc(C\C(=N/O)c2nc3ccc(OC)cc3o2)cc1
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InChI
InChI=1S/C17H16N2O4/c1-21-12-5-3-11(4-6-12)9-15(19-20)17-18-14-8-7-13(22-2)10-16(14)23-17/h3-8,10,20H,9H2,1-2H3/b19-15+
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InChIKey
WQJSDXPDBPDENI-XDJHFCHBSA-N
Physicochemical Property
logP
3.266
Rotatable Bonds
5
Heavy Atom Count
23
Polar Areas
77.08
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145967497
ChEMBL ID
CHEMBL4228510
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03614, NACHT, LRR and PYD domains-containing protein 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 1220 nM
   TI
   LI
   LO
   TS
Protein ID: PT03343, Toll-like receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000870 HEK-Blue Null1-v Homo sapiens (Human)  1
1
IC50 = 540 nM
   TI
   LI
   LO
   TS