Brief Information of the Cell Line and Protein
Cell Line ID: CL000752 , PBMC iPSC #1
Category Induced pluripotent stem cell
Organism
Homo sapiens (Human)
Protein ID: PT01922 , Toll-like receptor 9
Gene Name TLR9
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q9NR96
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000752  Protein ID: PT01922
 
Compound ID Compound Name Compound Formula
CP0424056
1,3-dimethyl-5-(7-methyl-2-piperidin-4-ylindazol-5-yl)pyridin-2-one
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C20H24N4O
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0388424
2-[4-[2-(3,4-dimethoxyphenyl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
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C27H37N3O2
 1
1
IC50 = 510 nM
   TI
   LI
   LO
   TS
CP0950854
2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole
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C23H29N3
 1
1
IC50 = 560 nM
   TI
   LI
   LO
   TS
CP0409312
1-methyl-5-(7-methyl-2-piperidin-4-ylindazol-5-yl)pyridin-2-one
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C19H22N4O
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0531875
5-[2-(4-cyclobutylpiperazin-1-yl)quinazolin-6-yl]-1-methylpyridin-2-one
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C22H25N5O
 1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0409314
1,4-dimethyl-5-(7-methyl-2-piperidin-4-ylindazol-5-yl)pyridin-2-one
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C20H24N4O
 1
1
IC50 = 7200 nM
   TI
   LI
   LO
   TS
CP0424053
1-methyl-5-[8-methyl-2-(4-propan-2-ylpiperazin-1-yl)quinazolin-6-yl]pyridin-2-one
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C22H27N5O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0525568
1,6-dimethyl-5-(7-methyl-2-piperidin-4-ylindazol-5-yl)pyridin-2-one
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C20H24N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0941521
5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-N-((3R,4R)-3-fluoropiperidin-4-yl)-1H-indazol-3-amine
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C22H26FN5
 1
1
IC50 > 570 nM
   TI
   LI
   LO
   TS
CP0528718
5-methoxy-6-pyridin-4-yl-1H-indole
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C14H12N2O
 1
1
IC50 > 3600 nM
   TI
   LI
   LO
   TS
CP0424067
8-[2-[(3S,4S)-3-fluoropiperidin-4-yl]-7-(trifluoromethyl)indazol-5-yl]-2,3-dihydro-1H-indolizin-5-one
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C21H20F4N4O
 1
1
IC50 > 5300 nM
   TI
   LI
   LO
   TS