Brief Information of the Cell Line and Protein
Cell Line ID: CL000262 , MT-2
Synonyms
MT2
MT-2J
MT-2Org
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2631
Protein ID: PT00004 , Pol polyprotein
Gene Name POL
Organism Human immunodeficiency virus 1
Protein Classification Enzyme
Uniprot ID Q72874
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000262  Protein ID: PT00004
 
Compound ID Compound Name Compound Formula
CP0470011
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[[4-(1,3-thiazol-2-yl)phenyl]methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C36H50N6O7S
 1
1
ED50 = 0.5 nM
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CP0374661
((S)-1-{(1S,2S)-1-Benzyl-3-[N-biphenyl-4-ylmethyl-N'-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-hydrazino]-2-hydroxy-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C38H51N5O7
 1
1
ED50 = 0.7 nM
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CP0461863
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C39H53N5O7
 1
1
ED50 = 0.7 nM
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CP0393864
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[[4-(1,3-thiazol-5-yl)phenyl]methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C36H50N6O7S
 1
1
ED50 = 0.8 nM
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CP0402881
((S)-1-{N'-[(2S,3S)-2-Hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-N'-[4-(2-methyl-2H-tetrazol-5-yl)-benzyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C35H51N9O7
 1
1
ED50 = 0.8 nM
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CP0407108
((S)-1-{N'-[4-(2-tert-Butyl-2H-tetrazol-5-yl)-benzyl]-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C38H57N9O7
 1
1
ED50 = 0.8 nM
   TI
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CP0448357
((S)-1-{(1S,2S)-1-Benzyl-3-[N'-((S)-2-ethoxycarbonylamino-3-methyl-butyryl)-N-(4-thiazol-5-yl-benzyl)-hydrazino]-2-hydroxy-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C36H50N6O7S
 1
1
ED50 = 1.2 nM
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CP0086074
Atazanavir
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C38H52N6O7
 1
1
ED50 = 1.4 nM
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CP0393763
methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[[4-(1,3-thiazol-5-yl)phenyl]methyl]amino]-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C35H48N6O7S
 1
1
ED50 = 1.4 nM
   TI
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CP0377608
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C38H51N5O7
 1
1
ED50 = 1.5 nM
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CP0378062
((S)-1-{N'-(4-Diethylamino-benzyl)-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C37H58N6O7
 1
1
ED50 = 1.6 nM
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CP0377953
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2-methyl-propyl)-carbamic acid methyl ester
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C37H49N5O7
 1
1
ED50 = 1.8 nM
   TI
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CP0477083
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C35H48N6O7S
 1
1
ED50 = 1.9 nM
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CP0461114
methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[(4-pyridin-2-ylphenyl)methyl]amino]-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C37H50N6O7
 1
1
ED50 = 2 nM
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CP0393762
methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[[4-(1,3-thiazol-2-yl)phenyl]methyl]amino]-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C35H48N6O7S
 1
1
ED50 = 2.1 nM
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CP0407134
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
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C37H50N6O7
 1
1
ED50 = 2.6 nM
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CP0383122
methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]amino]-(3-methylbutyl)amino]-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C29H49N5O7
 1
1
ED50 = 2.7 nM
   TI
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CP0377882
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propylcarbamoyl}-2-methyl-butyl)-carbamic acid methyl ester
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C37H50N6O7
 1
1
ED50 = 2.8 nM
   TI
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   TS
CP0402651
methyl N-[(2S)-1-[[(2S,3S)-4-[[[(2S)-2-(ethoxycarbonylamino)-3-methylbutanoyl]amino]-[(4-pyridin-2-ylphenyl)methyl]amino]-3-hydroxy-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C37H50N6O7
 1
1
ED50 = 5.4 nM
   TI
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CP0477154
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]amino]-4-phenylbutyl]-2-[[4-(1,3-thiazol-5-yl)phenyl]methyl]hydrazinyl]-3-methyl-1-oxobutan-2-yl]carbamate
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C34H46N6O7S
 1
1
ED50 = 5.6 nM
   TI
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CP0374662
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3-methyl-1-oxobutan-2-yl]carbamate
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C36H48N6O7
 1
1
ED50 = 7.4 nM
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CP0407058
CGP 53820 analog
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C33H55N5O7
 1
1
ED50 = 55 nM
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CP0874499
3-{(4R,5R,6R)-3-[3-((E)-1-Amino-2-hydroxy-vinyl)-phenyl]-4-benzyl-5-hydroxy-2-oxo-6-phenethyl-tetrahydro-pyrimidin-1-yl}-N-hydroxy-benzamidine
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C34H35N5O4
 1
1
Ki = 0.0182 nM
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CP0483228
3-[(4R,5R,6R)-4-benzyl-3-(3-carbamoylphenyl)-5-hydroxy-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]benzamide
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C33H32N4O4
 1
1
Ki = 0.0871 nM
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CP0448879
(4R,5R,6R)-1,3-bis(3-amino-4-fluorophenyl)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,3-diazinan-2-one
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C31H30F2N4O2
 1
1
Ki = 0.2512 nM
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CP0409242
(4R,5R,6R)-4-benzyl-5-hydroxy-1,3-bis(3-hydroxyphenyl)-6-(2-phenylethyl)-1,3-diazinan-2-one
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C31H30N2O4
 1
1
Ki = 0.302 nM
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CP0514174
(4R,5R,6R)-4-benzyl-5-hydroxy-1,3-bis[3-(hydroxymethyl)phenyl]-6-(2-phenylethyl)-1,3-diazinan-2-one
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C33H34N2O4
 1
1
Ki = 0.4898 nM
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CP0404856
5-[(4R,5R,6R)-4-benzyl-3-(3-carbamoyl-4-fluorophenyl)-5-hydroxy-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]-2-fluorobenzamide
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C33H30F2N4O4
 1
1
Ki = 1.413 nM
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CP0448865
methyl 3-[(4R,5R,6R)-4-benzyl-5-hydroxy-3-(3-methoxycarbonylphenyl)-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]benzoate
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C35H34N2O6
 1
1
Ki = 1.514 nM
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CP0502537
(4R,5R,6R)-1,3-bis(3-aminophenyl)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,3-diazinan-2-one
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C31H32N4O2
 1
1
Ki = 1.698 nM
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CP0523132
(4R,5R,6R)-4-benzyl-5-hydroxy-1,3-bis[4-(hydroxymethyl)phenyl]-6-(2-phenylethyl)-1,3-diazinan-2-one
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C33H34N2O4
 1
1
Ki = 2.512 nM
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CP0449401
(4R,5R,6R)-4-benzyl-5-hydroxy-1,3-bis[3-(methylamino)phenyl]-6-(2-phenylethyl)-1,3-diazinan-2-one
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C33H36N4O2
 1
1
Ki = 4.898 nM
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CP0525864
(4R,5R,6R)-1,3-bis(4-amino-3-fluorophenyl)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,3-diazinan-2-one
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C31H30F2N4O2
 1
1
Ki = 7.943 nM
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CP0409240
3-[(4R,5R,6R)-4-benzyl-3-(3-cyanophenyl)-5-hydroxy-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]benzonitrile
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C33H28N4O2
 1
1
Ki = 10.96 nM
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CP0376176
(4R,5R,6R)-4-benzyl-5-hydroxy-1,3-diphenyl-6-(2-phenylethyl)-1,3-diazinan-2-one
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C31H30N2O2
 1
1
Ki = 15.14 nM
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CP0933847
3-{(4S,5S,6S)-3-[3-((E)-1-Amino-2-hydroxy-vinyl)-phenyl]-4-benzyl-5-hydroxy-2-oxo-6-phenethyl-tetrahydro-pyrimidin-1-yl}-N-hydroxy-benzamidine
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C34H35N5O4
 1
1
Ki = 549.54 nM
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CP0404831
(4S,5S,6S)-4-benzyl-5-hydroxy-1,3-bis[3-(methylamino)phenyl]-6-(2-phenylethyl)-1,3-diazinan-2-one
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C33H36N4O2
 1
1
Ki = 776.25 nM
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CP0541565
methyl 4-[(4R,5R,6R)-4-benzyl-5-hydroxy-3-(4-methoxycarbonylphenyl)-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]benzoate
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C35H34N2O6
 1
1
Ki = 1949.84 nM
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CP0505097
3-[(4S,5S,6S)-4-benzyl-3-(3-carbamoylphenyl)-5-hydroxy-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]benzamide
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C33H32N4O4
 1
1
Ki = 3311.31 nM
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CP0376164
(4S,5S,6S)-1,3-bis(3-aminophenyl)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,3-diazinan-2-one
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C31H32N4O2
 1
1
Ki = 4786.3 nM
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CP0541747
(4S,5S,6S)-1,3-bis(3-amino-4-fluorophenyl)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,3-diazinan-2-one
   Show/Hide
C31H30F2N4O2
 1
1
Ki = 7943.28 nM
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