| Compound ID |
Compound Name |
Compound Formula |
|
CP0318731
|
5-(Dimethyl-hydrazonomethyl)-N-[1-(3-fluoro-benzyl)-1H-indazol-5-yl]-pyrimidine-4,6-diamine
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|
C21H21FN8
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0281776
|
2-(4-((4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-6-aminopyrimidin-5-yl)methyleneamino)piperazin-1-yl)ethanol
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|
C25H28FN9O
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0163871
|
4-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-[(E)-morpholin-4-yliminomethyl]pyrimidine-4,6-diamine
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|
C23H23FN8O
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0664046
|
Lapatinib ditosylate
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|
C43H44ClFN4O11S3
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0039472
|
4-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-[(E)-piperidin-1-yliminomethyl]pyrimidine-4,6-diamine
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|
C24H25FN8
|
1
|
| 1 |
IC50 = 148 nM
|
|
|
|
CP0814233
|
N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-[(2,2,2-trifluoro-ethyl)-hydrazonomethyl]-pyrimidine-4,6-diamine
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|
C21H18F4N8
|
1
|
| 1 |
IC50 = 258 nM
|
|
|
|
CP0163868
|
4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-6-aminopyrimidine-5-carbaldehyde O-methyl oxime
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|
C20H18FN7O
|
1
|
| 1 |
IC50 = 301 nM
|
|
|
|
CP0647673
|
N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-(methyl-hydrazonomethyl)-pyrimidine-4,6-diamine
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|
C20H19FN8
|
1
|
| 1 |
IC50 = 361 nM
|
|
|
|
CP0340608
|
(S)-N4-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((2-(methoxymethyl)pyrrolidin-1-ylimino)methyl)pyrimidine-4,6-diamine
Show/Hide
|
C25H27FN8O
|
1
|
| 1 |
IC50 = 426 nM
|
|
|
|
CP0270656
|
4-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-[(E)-(4-methylpiperazin-1-yl)iminomethyl]pyrimidine-4,6-diamine
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|
C24H26FN9
|
1
|
| 1 |
IC50 = 509 nM
|
|
|
|
CP0230209
|
7-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrolo[2,3-d]pyridazine-2-carboxamide
Show/Hide
|
C26H26ClFN6O2
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0226749
|
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-methyl-N-(2-(4-methylpiperazin-1-yl)ethyl)-1H-pyrrolo[3,2-d]pyridazine-2-carboxamide
Show/Hide
|
C28H31ClFN7O2
|
1
|
| 1 |
IC50 = 843 nM
|
|
|
|
CP0150683
|
ethyl 4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-7-methyl-6H-pyrrolo[3,4-d]pyridazine-5-carboxylate
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|
C23H20ClFN4O3
|
1
|
| 1 |
IC50 = 934 nM
|
|
|
|
CP0150154
|
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2-(diethylamino)ethyl)-3-methyl-1H-pyrrolo[3,2-d]pyridazine-2-carboxamide
Show/Hide
|
C27H30ClFN6O2
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0163869
|
4-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-[(4-methoxyphenyl)iminomethyl]pyrimidine-4,6-diamine
Show/Hide
|
C26H22FN7O
|
1
|
| 1 |
IC50 = 1291 nM
|
|
|
|
CP0801534
|
ERLOTINIB HYDROCHLORIDE
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|
C22H24ClN3O4
|
1
|
| 1 |
IC50 = 1890 nM
|
|
|
|
CP0290287
|
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-methyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrolo[3,2-d]pyridazine-2-carboxamide
Show/Hide
|
C29H33ClFN7O2
|
1
|
| 1 |
IC50 = 2240 nM
|
|
|
|
CP0317818
|
7-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2-(diethylamino)ethyl)-1H-pyrrolo[2,3-d]pyridazine-2-carboxamide
Show/Hide
|
C26H28ClFN6O2
|
1
|
| 1 |
IC50 = 3840 nM
|
|
|
|
CP0061645
|
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-methyl-N-(2-morpholinoethyl)-1H-pyrrolo[3,2-d]pyridazine-2-carboxamide
Show/Hide
|
C27H28ClFN6O3
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0284439
|
4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-methyl-N-(2-morpholinoethyl)-1H-pyrrolo[3,2-d]pyridazine-2-carboxamide
Show/Hide
|
C26H28ClN7O3
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
