| Compound ID |
Compound Name |
Compound Formula |
|
CP0019304
|
4-amino-6-[[(1S)-1-(3-methyl-5-oxo-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C21H18N6OS
|
1
|
| 1 |
IC50 = 0.7943 nM
|
|
|
|
CP0017045
|
4-amino-6-[[(1S)-1-[3-methyl-6-[3-[[4-(2-morpholin-4-ylethyl)piperazin-1-yl]methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C32H39N9O2S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0018048
|
4-amino-6-[[(1S)-1-[3-methyl-6-[3-[[4-[methyl(2-methylpropyl)amino]piperidin-1-yl]methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C32H40N8OS
|
1
|
| 1 |
IC50 = 1.259 nM
|
|
|
|
CP0019307
|
4-amino-6-[[(1S)-1-[3-methyl-5-oxo-6-[[3-[[4-(2-phenylethoxy)butylamino]methyl]phenyl]methyl]-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C35H39N7O2S
|
1
|
| 1 |
IC50 = 1.259 nM
|
|
|
|
CP0022510
|
4-amino-6-[[(1S)-1-[6-[3-[[ethyl(2-morpholin-4-ylethyl)amino]methyl]phenyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C30H36N8O2S
|
1
|
| 1 |
IC50 = 1.259 nM
|
|
|
|
CP0018051
|
4-amino-6-[[(1S)-1-[3-methyl-5-oxo-6-[3-[(1-propan-2-ylpiperidin-4-yl)methyl]phenyl]-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C30H35N7OS
|
1
|
| 1 |
IC50 = 1.585 nM
|
|
|
|
CP0019305
|
4-amino-6-[[(1S)-1-[3-methyl-6-[[3-[[methyl(2-methylpropyl)amino]methyl]phenyl]methyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C28H33N7OS
|
1
|
| 1 |
IC50 = 1.585 nM
|
|
|
|
CP0025106
|
4-amino-6-[[(1S)-1-[6-[[3-[(dimethylamino)methyl]phenyl]methyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C25H27N7OS
|
1
|
| 1 |
IC50 = 1.585 nM
|
|
|
|
CP0018049
|
4-amino-6-[[(1S)-1-[3-methyl-6-[3-[[4-[[methyl(pyridin-2-ylmethyl)amino]methyl]piperidin-1-yl]methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C35H39N9OS
|
1
|
| 1 |
IC50 = 1.995 nM
|
|
|
|
CP0018050
|
4-amino-6-[[(1S)-1-[6-[3-[[4-[benzyl(methyl)amino]butyl-methylamino]methyl]phenyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C35H40N8OS
|
1
|
| 1 |
IC50 = 1.995 nM
|
|
|
|
CP0017047
|
4-amino-6-[[(1S)-1-[6-[[3-[(2-methoxyethylamino)methyl]phenyl]methyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C26H29N7O2S
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0019306
|
4-amino-6-[[(1S)-1-[6-[[3-(azetidin-1-ylmethyl)phenyl]methyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C26H27N7OS
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0023939
|
4-amino-6-[[(1S)-1-[6-[3-[2-(dimethylamino)ethyl]phenyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C25H27N7OS
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0025105
|
4-amino-6-[[(1S)-1-[3-methyl-6-[3-[[4-[[methyl(2-methylpropyl)amino]methyl]piperidin-1-yl]methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C33H42N8OS
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0019308
|
4-amino-6-[[(1S)-1-[6-[3-[[3-[(4-chlorophenyl)methyl-methylamino]propyl-methylamino]methyl]phenyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C34H37ClN8OS
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0018311
|
4-amino-6-[[(1S)-1-[6-[3-[[3-[(2S,6R)-2,6-dimethylmorpholin-4-yl]propyl-methylamino]methyl]phenyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C32H40N8O2S
|
1
|
| 1 |
IC50 = 5.012 nM
|
|
|
|
CP0017053
|
4-amino-6-[[(1S)-1-[6-[3-[2-(dimethylamino)ethoxy]phenyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C25H27N7O2S
|
1
|
| 1 |
IC50 = 6.31 nM
|
|
|
|
CP0018312
|
4-amino-6-[[(1S)-1-[6-[3-[[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]butyl-methylamino]methyl]phenyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C33H42N8O2S
|
1
|
| 1 |
IC50 = 6.31 nM
|
|
|
|
CP0023537
|
4-amino-6-[[(1S)-1-[6-[3-[[4-(dimethylamino)piperidin-1-yl]methyl]phenyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C29H34N8OS
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0018313
|
4-amino-6-[[(1S)-1-[3-methyl-6-[3-[(2-morpholin-4-ylethylamino)methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C28H32N8O2S
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0023940
|
4-amino-6-[[(1S)-1-[3-methyl-6-[3-[[4-[methyl(3,3,3-trifluoropropyl)amino]piperidin-1-yl]methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C31H35F3N8OS
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0023014
|
4-amino-6-[[(1S)-1-[3-methyl-6-[[3-(methylaminomethyl)phenyl]methyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C24H25N7OS
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0030807
|
3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-5-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-amine
Show/Hide
|
C22H24N8O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0018052
|
4-amino-6-[[(1S)-1-[6-[[3-(aminomethyl)phenyl]methyl]-3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C23H23N7OS
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0046475
|
8-[(8-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide
Show/Hide
|
C25H26FN3O5
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0024290
|
4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]benzamide
Show/Hide
|
C23H21N7O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0016012
|
4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]-N,N-dimethylpyrazole-1-sulfonamide
Show/Hide
|
C21H23N9O2S
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0018780
|
5-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]-3-(1H-pyrazol-4-yl)pyrazin-2-amine
Show/Hide
|
C19H18N8
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0022456
|
4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]-2-fluorobenzamide
Show/Hide
|
C23H20FN7O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0019793
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-7-(methylsulfamoyl)-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
Show/Hide
|
C20H24N4O4S2
|
1
|
| 1 |
IC50 = 398.11 nM
|
|
|
|
CP0019791
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-7-(methanesulfonamido)-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
Show/Hide
|
C20H24N4O4S2
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0017013
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-7-methylsulfonyl-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
Show/Hide
|
C20H23N3O4S2
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0473312
|
7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one
Show/Hide
|
C18H20N8O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0571634
|
9-[(3R,4R)-4-fluoropyrrolidin-3-yl]-7-methyl-2-[(7-methylquinolin-6-yl)amino]purin-8-one
Show/Hide
|
C20H20FN7O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
