General Information of the Compound
Compound ID
CP0018313
Compound Name
4-amino-6-[[(1S)-1-[3-methyl-6-[3-[(2-morpholin-4-ylethylamino)methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
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Structure
Formula
C28H32N8O2S
Molecular Weight
544.685
Canonical SMILES
C[C@H](Nc1ncnc(N)c1C#N)c1cc2scc(C)n2c(=O)c1-c1cccc(CNCCN2CCOCC2)c1
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InChI
InChI=1S/C28H32N8O2S/c1-18-16-39-24-13-22(19(2)34-27-23(14-29)26(30)32-17-33-27)25(28(37)36(18)24)21-5-3-4-20(12-21)15-31-6-7-35-8-10-38-11-9-35/h3-5,12-13,16-17,19,31H,6-11,15H2,1-2H3,(H3,30,32,33,34)/t19-/m0/s1
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InChIKey
QXALODMNQYKXPN-IBGZPJMESA-N
Physicochemical Property
logP
3.1752
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
133.6
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
11
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137652944
ChEMBL ID
CHEMBL4091365
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00999, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000182 JeKo-1 Homo sapiens (Human)  1
1
IC50 = 12.59 nM
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