Brief Information of the Cell Line and Protein
Cell Line ID: CL000154 , HEK293-EBNA1-6E
Synonyms
HEK 293EBNA1-6E
HEK293-6E
HEK2936E
293-6E
293FEt-clone 6E
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_HF20
Protein ID: PT01934 , Serine/threonine-protein kinase ATR
Gene Name ATR
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q13535
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000154  Protein ID: PT01934
 
Compound ID Compound Name Compound Formula
CP0946954
3,3-Dimethyl-2-{2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-4-yl}butan-2-ol
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C22H29N5O2
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0068243
(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine
   Show/Hide
C21H24N4O3S
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0904636
2-[(3R)-3-Methylmorpholin-4-yl]-4-[4-(methylsulfonyl)piperazin-1-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C21H27N7O3S
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0639539
2-[(3R)-3-Methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C20H21N7O
 1
1
IC50 = 7 nM
   TI
   LI
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   TS
CP0946950
4-(2-Fluoropyridin-3-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C21H19FN6O
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0901623
N-(4-Fluorophenyl)-N-methyl-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-4-amine
   Show/Hide
C23H23FN6O
 1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CP0901624
4-(6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C22H23N7O
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0902619
4-[2-Methyl-6-(S-methylsulfonimidoyl)pyridin-3-yl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C23H25N7O2S
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0958487
2-[(3R)-3-Methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-4-(tetrahydro-2H-pyran-4-yl)-1,7-naphthyridine
   Show/Hide
C21H25N5O2
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0867459
2-[(3R)-3-Methylmorpholin-4-yl]-4-[1-(methylsulfonyl)-cyclopropyl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C20H23N5O3S
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0895134
2-[(3R)-3-Methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-4-(pyridin-3-ylethynyl)-1,7-naphthyridine
   Show/Hide
C23H20N6O
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0928862
4-{[Diethyl(oxido)-lambda6-sulfanylidene]amino}-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
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C20H26N6O2S
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0912067
4-(2-Methyl-1H-imidazol-1-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C20H21N7O
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0939308
4-(Diethylphosphoryl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
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C20H26N5O2P
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0958488
4-Isopropoxy-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
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C19H23N5O2
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0421059
US10772893, Example 7
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C22H21N5O3S
 1
1
IC50 = 59 nM
   TI
   LI
   LO
   TS
CP0527886
US10772893, Example 40
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C18H21N5O2
 1
1
IC50 = 125 nM
   TI
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   TS
CP0938246
4-Isopropoxy-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
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C20H23N5O2
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0540068
US10772893, Example 41
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C19H22N4O2
 1
1
IC50 = 339 nM
   TI
   LI
   LO
   TS
CP0904637
2-[(3R,5S)-3,5-Dimethylmorpholin-4-yl]-4-isopropoxy-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C20H25N5O2
 1
1
IC50 = 413 nM
   TI
   LI
   LO
   TS
CP0517577
2-(morpholin-4-yl)-4-(propan-2-yloxy)-8-(1H-pyrrol-3-yl)-1,7-naphthyridine
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C19H22N4O2
 1
1
IC50 = 589 nM
   TI
   LI
   LO
   TS
CP0864290
2-[(3R,5R)-3,5-Dimethylmorpholin-4-yl]-4-isopropoxy-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C20H25N5O2
 1
1
IC50 = 730 nM
   TI
   LI
   LO
   TS
CP0864291
4-Isopropoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C19H21N5O2
 1
1
IC50 = 922 nM
   TI
   LI
   LO
   TS
CP0895131
4-Isopropoxy-2-[(3S)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C19H23N5O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0958489
4-Isopropoxy-2-[(2R)-2-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C19H23N5O2
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0948315
4-Isopropoxy-2-(2-oxa-5-azabicyclo[4.1.0]heptan-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C19H21N5O2
 1
1
IC50 = 1510 nM
   TI
   LI
   LO
   TS
CP0946953
2-(3-Ethylmorpholin-4-yl)-4-isopropoxy-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C20H25N5O2
 1
1
IC50 = 1860 nM
   TI
   LI
   LO
   TS
CP0895132
4-Isopropoxy-2-[(2S)-2-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C19H23N5O2
 1
1
IC50 = 1970 nM
   TI
   LI
   LO
   TS
CP0473063
2-morpholin-4-yl-4-propan-2-yloxy-1,7-naphthyridine-8-carboxamide
   Show/Hide
C16H20N4O3
 1
1
IC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0540735
4-[8-(1H-imidazol-5-yl)-4-propan-2-yloxy-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C18H21N5O2
 1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0460848
4-[4-propan-2-yloxy-8-(1H-pyrazol-4-yl)-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C18H21N5O2
 1
1
IC50 = 3690 nM
   TI
   LI
   LO
   TS
CP0487645
4-[4-propan-2-yloxy-8-(1H-pyrazol-5-yl)quinolin-2-yl]morpholine
   Show/Hide
C19H22N4O2
 1
1
IC50 = 5050 nM
   TI
   LI
   LO
   TS
CP0540736
4-[8-(4-methyl-1H-pyrazol-5-yl)-4-propan-2-yloxy-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C19H23N5O2
 1
1
IC50 = 5640 nM
   TI
   LI
   LO
   TS
CP0946949
4-Isopropoxy-8-(1H-pyrazol-5-yl)-2-[3-(trifluoromethyl)-morpholin-4-yl]-1,7-naphthyridine
   Show/Hide
C19H20F3N5O2
 1
1
IC50 = 8610 nM
   TI
   LI
   LO
   TS
CP0895133
4-Isopropoxy-8-(1H-pyrazol-5-yl)-2-[(3aR,6aS)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl]-1,7-naphthyridine
   Show/Hide
C20H23N5O2
 1
1
IC50 = 9440 nM
   TI
   LI
   LO
   TS
CP0468942
4-[8-(2-methylpyrazol-3-yl)-4-propan-2-yloxy-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C19H23N5O2
 1
1
IC50 = 12500 nM
   TI
   LI
   LO
   TS
CP0460850
4-[8-(5-methyl-1H-pyrazol-3-yl)-4-propan-2-yloxy-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C19H23N5O2
 1
1
IC50 = 12700 nM
   TI
   LI
   LO
   TS
CP0473129
4-[8-(6-methoxypyridin-2-yl)-4-propan-2-yloxy-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C21H24N4O3
 1
1
IC50 = 13200 nM
   TI
   LI
   LO
   TS
CP0539217
3-(2-morpholin-4-yl-4-propan-2-yloxy-1,7-naphthyridin-8-yl)benzamide
   Show/Hide
C22H24N4O3
 1
1
IC50 = 17200 nM
   TI
   LI
   LO
   TS
CP0525622
4-(4-propan-2-yloxy-8-pyridin-3-yl-1,7-naphthyridin-2-yl)morpholine
   Show/Hide
C20H22N4O2
 1
1
IC50 = 18100 nM
   TI
   LI
   LO
   TS
CP0471022
2-(3-methoxy-3-methylazetidin-1-yl)-4-propan-2-yloxy-8-(1H-pyrazol-5-yl)-1,7-naphthyridine
   Show/Hide
C19H23N5O2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0473064
4-[4-propan-2-yloxy-8-(2H-tetrazol-5-yl)-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C16H19N7O2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0473065
N-methyl-2-morpholin-4-yl-4-propan-2-yloxy-1,7-naphthyridine-8-carboxamide
   Show/Hide
C17H22N4O3
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0473131
6-(2-morpholin-4-yl-4-propan-2-yloxy-1,7-naphthyridin-8-yl)-1H-pyridin-2-one
   Show/Hide
C20H22N4O3
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0475219
3-(2-morpholin-4-yl-4-propan-2-yloxy-1,7-naphthyridin-8-yl)-1H-pyridin-2-one
   Show/Hide
C20H22N4O3
 1
1
IC50 > 20000 nM
   TI
   LI
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   TS
CP0487643
4-(4-propan-2-yloxy-8-pyrrolidin-3-yl-1,7-naphthyridin-2-yl)morpholine
   Show/Hide
C19H26N4O2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0487644
4-(4-propan-2-yloxy-1,7-naphthyridin-2-yl)morpholine
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C15H19N3O2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0487647
2,2,6,6-tetrafluoro-4-[4-propan-2-yloxy-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C18H17F4N5O2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0517576
3,3-dimethyl-4-[4-propan-2-yloxy-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C20H25N5O2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0540072
4-[8-(1H-indol-2-yl)-4-propan-2-yloxy-1,7-naphthyridin-2-yl]morpholine
   Show/Hide
C23H24N4O2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS