| Compound ID |
Compound Name |
Compound Formula |
|
CP0148736
|
N-[3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
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|
C18H18F3N5O2S
|
2
|
| 1 |
IC50 = 0.38 nM
|
|
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| 2 |
IC50 = 1 nM
|
|
|
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CP0528126
|
N-[3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyridine-2-carboxamide
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|
C19H19F3N4O2S
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
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CP0546422
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-methylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-3,3-difluoro-2H-[1,4]dioxino[2,3-c]pyridine-7-carboxamide
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|
C22H22F4N4O5S
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
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CP0573259
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-methylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
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|
C20H22F3N5O4S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
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CP0344306
|
N-[3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide
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|
C20H20F2N4O3S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
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CP0955263
|
N-(3-((2S,5R)-6-Amino-2-(fluoromethyl)-5-methyl-5-(methylsulfonyl)-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-2,2,3,3-d4-7-carboxamide
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|
C22H24F2N4O5S
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0275908
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-methylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide
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|
C22H24F2N4O5S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0066568
|
N-[3-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide
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|
C18H17ClF2N4O2
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0569658
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-methylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
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|
C20H21F3N4O3S
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0202840
|
N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
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|
C17H16ClFN4O2
|
1
|
| 1 |
IC50 = 4.1 nM
|
|
|
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CP0262055
|
N-[3-[(2S,5R)-6-amino-5-ethylsulfonyl-2-(fluoromethyl)-5-methyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-2,2-difluoro-[1,3]dioxolo[4,5-c]pyridine-6-carboxamide
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|
C22H22F4N4O5S
|
1
|
| 1 |
IC50 = 5.1 nM
|
|
|
|
CP0066567
|
N-[3-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
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|
C17H15ClF2N4O2
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0188117
|
N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
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|
C17H18FN5O3
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0573829
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-methylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-2,2-difluoro-[1,3]dioxolo[4,5-c]pyridine-6-carboxamide
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|
C21H20F4N4O5S
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0275907
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-propan-2-ylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-2,2-difluoro-[1,3]dioxolo[4,5-c]pyridine-6-carboxamide
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|
C23H24F4N4O5S
|
1
|
| 1 |
IC50 = 6.8 nM
|
|
|
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CP0067274
|
N-[3-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
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|
C18H15F2N5O2
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
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CP0074572
|
N-[3-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
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|
C17H17F2N5O3
|
1
|
| 1 |
IC50 = 9.1 nM
|
|
|
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CP0204164
|
N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]phenyl]-5-chloropyridine-2-carboxamide
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|
C17H17ClN4O2
|
1
|
| 1 |
IC50 = 9.1 nM
|
|
|
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CP0267201
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-methylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-[1,3]dioxolo[4,5-c]pyridine-6-carboxamide
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|
C21H22F2N4O5S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
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CP0067272
|
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyrazine-2-carboxamide
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|
C17H14ClF4N5O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
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CP0204165
|
N-[3-[(2S,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyrazine-2-carboxamide
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|
C17H14ClF4N5O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0574131
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-methylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-6-methoxypyrimidine-4-carboxamide
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|
C20H23F2N5O4S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0330022
|
N-[3-(5-amino-1,3-dimethyl-6-oxo-2H-pyrazin-3-yl)-4-fluorophenyl]-5-chloropyridine-2-carboxamide
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|
C18H17ClFN5O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0545523
|
N-[3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-3,4-dihydro-2H-pyrano[3,2-c]pyridine-7-carboxamide
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|
C21H22F2N4O2S
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
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CP0074397
|
N-[3-[(5R,6S)-3-amino-6-fluoro-5-methyl-6-(trifluoromethyl)-2H-1,4-oxazin-5-yl]-4-fluorophenyl]-5-chloropyrazine-2-carboxamide
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|
C17H13ClF5N5O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
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CP0335732
|
N-[3-[(5R)-3-amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl]phenyl]-5-chloropyridine-2-carboxamide
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|
C18H18ClN5O2
|
2
|
| 1 |
IC50 = 36 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
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CP0152027
|
N-[3-(3-amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl)phenyl]-5-(trifluoromethyl)pyridine-2-carboxamide
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|
C19H18F3N5O2
|
2
|
| 1 |
IC50 = 68 nM
|
|
|
| 2 |
IC50 = 79 nM
|
|
|
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CP0267202
|
N-[3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-methylsulfonyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-3,4-dihydro-2H-[1,4]dioxepino[2,3-c]pyridine-8-carboxamide
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|
C23H26F2N4O5S
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
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CP0214777
|
N-[3-(3-amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl)phenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C18H18ClN5O2
|
2
|
| 1 |
IC50 = 78 nM
|
|
|
| 2 |
IC50 = 98 nM
|
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CP0545415
|
N-[3-[(2S,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Show/Hide
|
C17H17F2N5O3
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
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CP0546201
|
N-[3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carboxamide
Show/Hide
|
C21H22F2N4O2S
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
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CP0238445
|
N-[3-(3-amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl)phenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C19H18N6O2
|
2
|
| 1 |
IC50 = 151 nM
|
|
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| 2 |
IC50 = 186 nM
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CP0188118
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N-[2-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]pyridin-4-yl]-5-methoxypyrazine-2-carboxamide
Show/Hide
|
C16H17FN6O3
|
1
|
| 1 |
IC50 = 257 nM
|
|
|
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CP0074398
|
N-[3-[(5R,6R)-3-amino-6-fluoro-5-methyl-6-(trifluoromethyl)-2H-1,4-oxazin-5-yl]-4-fluorophenyl]-5-chloropyrazine-2-carboxamide
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|
C17H13ClF5N5O2
|
1
|
| 1 |
IC50 = 324 nM
|
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CP0538933
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N-[3-[(2R,3R)-5-amino-3-cyclopropyl-2-fluoro-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
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|
C19H19F2N5O3
|
1
|
| 1 |
IC50 = 603 nM
|
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CP0152028
|
N-[3-(3-amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl)phenyl]-5-methylpyrazine-2-carboxamide
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|
C18H20N6O2
|
2
|
| 1 |
IC50 = 1148 nM
|
|
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| 2 |
IC50 = 1259 nM
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CP0204166
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N-[4-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]pyridin-2-yl]-5-methoxypyrazine-2-carboxamide
Show/Hide
|
C16H17FN6O3
|
1
|
| 1 |
IC50 = 1445 nM
|
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CP0275309
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N-[3-[(5S)-3-amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl]phenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C18H18ClN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
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|
