Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[3-(3-amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl)phenyl]-5-cyanopyridine-2-carboxamide
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 PubChem ID
CID: 54760134
SID: 131524287
Canonical SMILES
CN1CC(N)=NC(C)(C1=O)c1cccc(NC(=O)c2ccc(cn2)C#N)c1
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Compound Formula C19H18N6O2
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000151 SK-N-BE(2)
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 151 nM
   TI
   LI
   LO
   TS
2
IC50 = 186 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 813 nM