| Compound ID |
Compound Name |
Compound Formula |
|
CP0452088
|
5-(5-ethyl-5-methyl-6-oxo-1,4-dihydropyridin-3-yl)-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamide
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|
C21H20FN3O4S2
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0424066
|
5-[(3S,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamide
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|
C17H15F2N3O4S2
|
1
|
| 1 |
EC50 = 7.9 nM
|
|
|
|
CP0139504
|
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide
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|
C17H16FN3O4S2
|
2
|
| 1 |
EC50 = 8 nM
|
|
|
| 2 |
EC50 = 356 nM
|
|
|
|
CP0558351
|
5-(5,5-dimethyl-6-oxo-1,4-dihydropyridin-3-yl)-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamide
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|
C20H18FN3O4S2
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0452087
|
5-[(3R,4S)-3-fluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamide
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|
C17H15F2N3O4S2
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0424065
|
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3S)-3-hydroxypiperidin-1-yl]thiophene-2-sulfonamide
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|
C18H18FN3O4S2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0513923
|
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-(4-hydroxypiperidin-1-yl)thiophene-2-sulfonamide
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|
C18H18FN3O4S2
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0462240
|
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3S)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide
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|
C17H16FN3O4S2
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0556183
|
5-[(4R)-3,3-difluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamide
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|
C17H14F3N3O4S2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0564239
|
5-[(4S)-3,3-difluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamide
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|
C17H14F3N3O4S2
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0574529
|
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-(6-oxo-1H-pyridin-3-yl)thiophene-2-sulfonamide
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|
C18H12FN3O4S2
|
1
|
| 1 |
EC50 = 62 nM
|
|
|
|
CP0539252
|
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3R)-3-hydroxypiperidin-1-yl]thiophene-2-sulfonamide
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|
C18H18FN3O4S2
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0507069
|
4-cyano-N-(1-oxo-2H-isoquinolin-7-yl)benzenesulfonamide
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|
C16H11N3O3S
|
1
|
| 1 |
EC50 = 567 nM
|
|
|
|
CP0539251
|
4-cyano-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)benzenesulfonamide
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|
C16H10FN3O3S
|
1
|
| 1 |
EC50 = 1811 nM
|
|
|
