General Information of the Compound
Compound ID
CP0507069
Compound Name
4-cyano-N-(1-oxo-2H-isoquinolin-7-yl)benzenesulfonamide
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Structure
Formula
C16H11N3O3S
Molecular Weight
325.349
Canonical SMILES
O=c1[nH]ccc2ccc(NS(=O)(=O)c3ccc(cc3)C#N)cc12
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InChI
InChI=1S/C16H11N3O3S/c17-10-11-1-5-14(6-2-11)23(21,22)19-13-4-3-12-7-8-18-16(20)15(12)9-13/h1-9,19H,(H,18,20)
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InChIKey
SGMOXFPDJMEPRG-UHFFFAOYSA-N
Physicochemical Property
logP
2.20058
Rotatable Bonds
3
Heavy Atom Count
23
Polar Areas
102.82
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137653705
ChEMBL ID
CHEMBL4092503
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02379, Bifunctional purine biosynthesis protein ATIC
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000145 NCI-H460 Homo sapiens (Human)  1
1
EC50 = 567 nM
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