Brief Information of the Cell Line and Protein
Cell Line ID: CL000111 , MDA-MB-231
Synonyms
MDA_MB_231
MDA-MB 231
MDA.MB.231
MDA MB 231
MDA MB231
MDA Mb231
MDA-MB231
MDAMB-231
MDAMB231
MDA-231
MDA-231P
MDA231
MDA231-BRE
MB231
MD Anderson-Metastatic Breast-231
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0062
Protein ID: PT01557 , Indoleamine 2,3-dioxygenase 1
Gene Name IDO1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P14902
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000111  Protein ID: PT01557
 
Compound ID Compound Name Compound Formula
CP0132323
8-(3,4-difluorophenyl)-10-methyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraen-6-amine
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C14H11F2N5O
 1
1
EC50 = 48 nM
   TI
   LI
   LO
   TS
CP0132320
8-(3-chloro-4-fluorophenyl)-6,10-dimethyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraene
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C15H12ClFN4O
 1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0240313
5-(3-chlorophenyl)-2,4,7-trioxo-1,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
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C14H7ClN4O3
 1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0236732
4-amino-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide
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C9H7ClFN5O2
 1
1
EC50 = 59 nM
   TI
   LI
   LO
   TS
CP0419644
8-(3,4-difluorophenyl)-6,10-dimethyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraene
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C15H12F2N4O
 1
1
EC50 = 71 nM
   TI
   LI
   LO
   TS
CP0446559
8-(3,4-difluorophenyl)-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraene-6,10-diamine
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C13H10F2N6O
 1
1
EC50 = 73 nM
   TI
   LI
   LO
   TS
CP0481775
7-amino-5-(3-chlorophenyl)-2,4-dioxo-5,8-dihydro-1H-pyrido[2,3-d]pyrimidine-6-carbonitrile
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C14H10ClN5O2
 1
1
EC50 = 75 nM
   TI
   LI
   LO
   TS
CP0458137
8-(3,4-difluorophenyl)-6-methyl-2-oxa-4,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3,6-triene-10,12-dione
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C15H10F2N4O3
 1
1
EC50 = 76 nM
   TI
   LI
   LO
   TS
CP0419645
8-(3-chloro-4-fluorophenyl)-10-methyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraen-6-amine
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C14H11ClFN5O
 1
1
EC50 = 81 nM
   TI
   LI
   LO
   TS
CP0518092
8-(3-chloro-4-fluorophenyl)-6-methyl-2-oxa-4,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3,6-triene-10,12-dione
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C15H10ClFN4O3
 1
1
EC50 = 83 nM
   TI
   LI
   LO
   TS
CP0477612
5-(6-amino-10-methyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraen-8-yl)-2-methoxyphenol
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C15H15N5O3
 1
1
EC50 = 113 nM
   TI
   LI
   LO
   TS
CP0518093
8-(4-fluorophenyl)-6,10-dimethyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraene
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C15H13FN4O
 1
1
EC50 = 135 nM
   TI
   LI
   LO
   TS
CP0477613
8-(3-chloro-4-fluorophenyl)-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraene-6,10-diamine
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C13H10ClFN6O
 1
1
EC50 = 139 nM
   TI
   LI
   LO
   TS
CP0666099
1-(5-Chloro-2-oxoindolin-3-ylidene)pentane-2,4-dione
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C13H10ClNO3
 1
1
EC50 = 330 nM
   TI
   LI
   LO
   TS
CP0751153
(3Z)-1H-indole-2,3-dione 3-[(4-chlorophenyl)hydrazone]
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C14H10ClN3O
 1
1
EC50 = 420 nM
   TI
   LI
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   TS
CP0688886
5-Chloro-3-(2-oxopropylidene)indole-2-one
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C11H8ClNO2
 1
1
EC50 = 460 nM
   TI
   LI
   LO
   TS
CP0731354
(2S)-2-acetamido-3-(2-oxoindolin-3-yl)propanoic acid
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C13H14N2O4
 1
1
EC50 = 480 nM
   TI
   LI
   LO
   TS
CP0666136
1-(3-Hydroxy-2-oxoindolin-3-yl)pentane-2,4-dione
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C13H13NO4
 1
1
EC50 = 490 nM
   TI
   LI
   LO
   TS
CP0691624
(2S)-2-(benzyloxycarbonylamino)-3-(2-oxoindolin-3-yl)propanoic acid
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C19H18N2O5
 1
1
EC50 = 1260 nM
   TI
   LI
   LO
   TS