Brief Information of the Cell Line and Protein
Cell Line ID: CL000109 , COS-1
Synonyms
Cos-1
COS 1
Cos 1
COS1
Cos1
CV-1 in Origin Simian-1
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0223
Protein ID: PT01919 , Peroxisome proliferator-activated receptor alpha
Gene Name PPARA
Organism Mus musculus, Mouse
Protein Classification Transcription factor
Uniprot ID P23204
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000109  Protein ID: PT01919
 
Compound ID Compound Name Compound Formula
CP0070863
(2R)-2-[3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy]propanoicAcid
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C27H21ClF3NO5
 1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
CP0174902
(2R)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}isobutyric Acid
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C29H25ClF3NO5
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0108857
(2R)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}pentanoic Acid
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C29H25ClF3NO5
 1
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
CP0043911
(2R)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}butanoic Acid
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C28H23ClF3NO5
 1
1
EC50 = 120 nM
   TI
   LI
   LO
   TS
CP0174901
1-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}-1-cyclobutanecarboxylic Acid
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C29H23ClF3NO5
 1
1
EC50 = 150 nM
   TI
   LI
   LO
   TS
CP0293295
2-[3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1Hindol-1-yl]methyl]phenoxy]acetic Acid
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C26H19ClF3NO5
 1
1
EC50 = 350 nM
   TI
   LI
   LO
   TS
CP0108856
(2S)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}isobutyric Acid
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C29H25ClF3NO5
 1
1
EC50 = 360 nM
   TI
   LI
   LO
   TS
CP0380855
2-(3-(3-(2-(4-methylbenzoyl)-1H-pyrrol-1-yl)prop-1-enyl)phenoxy)acetic acid
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C23H21NO4
 1
1
EC50 = 4900 nM
   TI
   LI
   LO
   TS
CP0293294
(+)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}-2-methylbutanoic Acid
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C29H25ClF3NO5
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0005387
Avandamet
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C18H19N3O3S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0048728
(2S)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}butanoic Acid
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C28H23ClF3NO5
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0259373
(2S)-2-[3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy]propanoicAcid
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C27H21ClF3NO5
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0282604
(2S)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}pentanoic Acid
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C29H25ClF3NO5
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0316148
2-(3-((1-(4-chlorobenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)acetic acid
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C26H19ClF3NO5
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS