Brief Information of the Cell Line and Protein
Cell Line ID: CL000073 , A-498
Synonyms
A498
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1056
Protein ID: PT01142 , Vascular endothelial growth factor receptor 1
Gene Name FLT1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P17948
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000073  Protein ID: PT01142
 
Compound ID Compound Name Compound Formula
CP0063796
Anilinoquinazoline deriv. 4
   Show/Hide
C16H13ClFN3O2
 2
1
IC50 = 14100 nM
   TI
   LI
   LO
   TS
2
IC50 = 17700 nM
   TI
   LI
   LO
   TS
CP0395235
4-N-(4-chlorophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C21H20ClN5O2
 1
1
IC50 = 15200 nM
   TI
   LI
   LO
   TS
CP0126790
4-N-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C23H18BrN5
 1
1
IC50 = 16000 nM
   TI
   LI
   LO
   TS
CP0392884
4-N-(4-chloro-2-fluorophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C20H17ClFN5
 1
1
IC50 = 19200 nM
   TI
   LI
   LO
   TS
CP0096083
4-N-(3-bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C21H20BrN5O2
 2
1
IC50 = 31100 nM
   TI
   LI
   LO
   TS
2
IC50 = 45900 nM
   TI
   LI
   LO
   TS
CP0391385
4-N-(4-chlorophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C23H18ClN5
 1
1
IC50 = 31100 nM
   TI
   LI
   LO
   TS
CP0167979
4-N-(3-bromophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C20H18BrN5
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0275218
4-N-(3-bromophenyl)-6-[(2,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H14BrCl2N5
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0410666
4-N-(3-bromophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H17BrN6
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0418813
4-N-(3-bromophenyl)-7-(naphthalen-2-ylmethyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C23H18BrN5
 1
1
IC50 = 50800 nM
   TI
   LI
   LO
   TS
CP0400032
4-N-(4-chloro-2-fluorophenyl)-6-[(2,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H13Cl3FN5
 1
1
IC50 = 70900 nM
   TI
   LI
   LO
   TS
CP0402192
4-N-(3-bromophenyl)-7-[(4-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H15BrClN5
 1
1
IC50 = 79900 nM
   TI
   LI
   LO
   TS
CP0417588
4-N-(3-bromo-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H16BrFN6
 1
1
IC50 = 93600 nM
   TI
   LI
   LO
   TS
CP0437754
7-benzyl-4-N-(3-bromophenyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H16BrN5
 1
1
IC50 = 99300 nM
   TI
   LI
   LO
   TS