Brief Information of the Cell Line and Protein
Cell Line ID: CL000067 , HCT 116
 Cell Line Info 
Synonyms
HCT-116
HCT.116
HCT_116
HCT116
HCT116wt
CoCL2
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0291
Protein ID: PT01462 , Bromodomain-containing protein 4
 Protein Info 
Gene Name BRD4
Organism Homo sapiens, Human
Protein Classification Epigenetic regulator
Uniprot ID O60885
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000067
 Cell Line Info 
 Protein ID: PT01462
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0086064
 Compound Info 
6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxobenzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione
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C25H23N3O4
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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   LO
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CP0127907
 Compound Info 
6-(3-hydroxypropyl)-2-(1-methyl-2-oxo-3H-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione
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C23H19N3O4
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0261967
 Compound Info 
(1R,9S,12R)-13-[8-[[1-(2-fluoro-2-methylpropyl)piperidin-4-yl]amino]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl]-12-propan-2-yl-11,13-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one
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C30H39FN8O2
  1
1
IC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0571907
 Compound Info 
(1R,9S,12R)-13-[3-methyl-8-(3-pyrrolidin-1-ylpropylamino)-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl]-12-propan-2-yl-11,13-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one
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C28H36N8O2
  1
1
IC50 = 25118.86 nM
 Bioactivity Info 
   TI
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   LO
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CP0489411
 Compound Info 
(1R,9S)-13-[3-methyl-8-[(1-methylpiperidin-4-yl)amino]-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl]-11,13-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one
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C24H28N8O2
  1
1
IC50 = 31622.78 nM
 Bioactivity Info 
   TI
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CP0575351
 Compound Info 
(1R,9S,12R)-13-[8-[3-(4,4-difluoropiperidin-1-yl)propylamino]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl]-12-propan-2-yl-11,13-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one
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C29H36F2N8O2
  1
1
IC50 = 31622.78 nM
 Bioactivity Info 
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CP0537714
 Compound Info 
(1R,9S,12R)-13-[8-[[1-(2,2-difluoropropyl)piperidin-4-yl]amino]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl]-12-propan-2-yl-11,13-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one
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C29H36F2N8O2
  1
1
IC50 = 50118.72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS